Peritoneal healing with adhesion formation: Current comment

Frederick H. Watkins, David B. Drake, Lena E. Holmdahl, Mary J. Cox, Margaret F. Fay, Richard F. Edlich

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Intra-abdominal adhesions are fibrotic structures, which lie in the form of a string or attachment between the abdominal organs and connect these together. They are responsible for serious clinical complications that include intestinal obstruction, infertility, and pelvic pain. During the last century, surgeons comprehensive understanding of the biology of peritoneal healing and wound repair has allowed them to identify a variety of new therapeutic techniques that limit the development of adhesion formation. New drugs, dextran 70 and poloxamer 407, have been developed to prevent adhesion formation. In addition, three new biomaterials (oxidized regenerated cellulose, hyaluronate membrane, and polytetrafluoroethylene) are synthetic barriers being used to prevent adhesions.

Original languageEnglish
Pages (from-to)139-154
Number of pages16
JournalJournal of Long-Term Effects of Medical Implants
Issue number2
StatePublished - 1997


  • Dextran 70
  • Hyaluronate membrane
  • Oxidized regenerated cellulose
  • Pelvic pain
  • Poloxamer 407
  • Polytetrafluoroethylene

ASJC Scopus subject areas

  • Biomedical Engineering
  • General Dentistry


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