TY - JOUR
T1 - Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Patients
AU - Yu, Inski
AU - Greenberg, Richard N.
AU - Crawford, Timothy N.
AU - Thornton, Alice C.
AU - Myint, Thein
N1 - Publisher Copyright:
© SAGE Publications.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - The duration of macrocytosis after stopping zidovudine (ZDV) is unknown. Among 104 HIV-infected patients treated with ZDV for more than 1 year, 84 patients had macrocytosis at ZDV discontinuation. The median mean corpuscular volume (MCV) was 114.6 fL (range 100-128 fL). Patients were divided into 2 groups: those who did (resolved macrocytosis, n = 36) and did not (persistent macrocytosis, n = 48) normalize MCV at 3 to 6 months after ZDV discontinuation. Alcohol use (P =.02), smoking (P =.03), and lower (but within normal range) folic acid levels (P =.05) were related to the persistence of macrocytosis. A persistence of macrocytosis was observed in 57% at 3 to 6 months, 38% at 1 year and 37% at 2 years after ZDV therapy had stopped. Duration of ZDV therapy did not have an effect on the persistence of macrocytosis (P =.73). The median time for the MCV to normalize after stopping ZDV was 12.5 months.
AB - The duration of macrocytosis after stopping zidovudine (ZDV) is unknown. Among 104 HIV-infected patients treated with ZDV for more than 1 year, 84 patients had macrocytosis at ZDV discontinuation. The median mean corpuscular volume (MCV) was 114.6 fL (range 100-128 fL). Patients were divided into 2 groups: those who did (resolved macrocytosis, n = 36) and did not (persistent macrocytosis, n = 48) normalize MCV at 3 to 6 months after ZDV discontinuation. Alcohol use (P =.02), smoking (P =.03), and lower (but within normal range) folic acid levels (P =.05) were related to the persistence of macrocytosis. A persistence of macrocytosis was observed in 57% at 3 to 6 months, 38% at 1 year and 37% at 2 years after ZDV therapy had stopped. Duration of ZDV therapy did not have an effect on the persistence of macrocytosis (P =.73). The median time for the MCV to normalize after stopping ZDV was 12.5 months.
KW - HIV
KW - discontinuation
KW - macrocytosis
KW - persistence
KW - zidovudine
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U2 - 10.1177/2325957417702486
DO - 10.1177/2325957417702486
M3 - Article
C2 - 28393661
AN - SCOPUS:85029494105
SN - 2325-9574
VL - 16
SP - 512
EP - 515
JO - Journal of the International Association of Providers of AIDS Care
JF - Journal of the International Association of Providers of AIDS Care
IS - 5
ER -
