TY - JOUR
T1 - Persistent infection and pancytopenia associated with ferret systemic coronaviral disease in a domestic ferret
AU - Tarbert, Danielle K.
AU - Bolin, Lisa L.
AU - Stout, Alison E.
AU - Schaefer, Deanna M.W.
AU - Ruby, Rebecca E.
AU - Rodriguez-Ramos Fernandez, Julia
AU - Duhamel, Gerald E.
AU - Whittaker, Gary R.
AU - de Matos, Ricardo
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Ferret systemic coronaviral disease (FSCD) is a well-established cause of mortality in domestic ferrets. We describe herein novel findings in a case of FSCD that was diagnosed and medically managed following virus detection by immunohistochemical (IHC) staining of surgical biopsy samples. Hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by IHC staining of a postmortem sample. Genotyping of the virus indicated that the virus grouped with alphacoronaviruses and was most closely related to ferret enteric coronavirus (FRECV) MSU-2. Our clinical case demonstrates that a FRECV MSU-2–like ferret coronavirus associated previously with the enteric pathotype may cause systemic disease, including bone marrow involvement causing persistent pancytopenia.
AB - Ferret systemic coronaviral disease (FSCD) is a well-established cause of mortality in domestic ferrets. We describe herein novel findings in a case of FSCD that was diagnosed and medically managed following virus detection by immunohistochemical (IHC) staining of surgical biopsy samples. Hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by IHC staining of a postmortem sample. Genotyping of the virus indicated that the virus grouped with alphacoronaviruses and was most closely related to ferret enteric coronavirus (FRECV) MSU-2. Our clinical case demonstrates that a FRECV MSU-2–like ferret coronavirus associated previously with the enteric pathotype may cause systemic disease, including bone marrow involvement causing persistent pancytopenia.
KW - Mustela putorius furo
KW - alphacoronavirus
KW - bone marrow
KW - ferret coronavirus MSU-2
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U2 - 10.1177/1040638720937105
DO - 10.1177/1040638720937105
M3 - Article
C2 - 32589111
AN - SCOPUS:85086853331
SN - 1040-6387
VL - 32
SP - 616
EP - 620
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
IS - 4
ER -