Abstract
Aims: To determine whether self-regulation can be studied successfully in a rodent model and whether persistent facial pain influences self-regulatory behavior. Methods: Thirty male Sprague-Dawley rats, divided into two groups, (1) chronic constriction injury of the infraorbital nerve (CCI-ION) and (2) naïve, were used in a two-part behavioral paradigm of self-regulation. This paradigm consisted of both a cued go/no-go task (part one) and a persistence trial (part two). All animals were acclimated and trained for a period of 4 weeks prior to the experimental manipulation and then tested for a total of 5 weeks following experimental manipulation. Results were analyzed with t tests, one-way analysis of variance, and two-way, repeated measures analysis of variance. Results: CCI-ION surgery induced significant mechanical hypersensitivity of the ipsilateral whisker pad that began 3 weeks postsurgery and persisted through the duration of the experiment (P <.001). At weeks 4 and 5 post-experimental manipulation, naïve animals demonstrated a significant decrease in lever presses during the persistence task (P <.05) compared to baseline, whereas CCI-ION animals did not (P =.55). Conclusion: These results suggest that persistent pain influences behavioral regulation and that animals experiencing persistent pain may have difficulty adapting to environmental demands.
Original language | English |
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Pages (from-to) | 183-192 |
Number of pages | 10 |
Journal | Journal of Oral and Facial Pain and Headache |
Volume | 29 |
Issue number | 2 |
DOIs | |
State | Published - 2015 |
Bibliographical note
Publisher Copyright:© 2015 by Quintessence Publishing Co Inc.
Keywords
- Chronic constrictive injury
- Infraorbital nerve
- Learning
- Orofacial pain
- Self-regulation
ASJC Scopus subject areas
- Dentistry (miscellaneous)
- Clinical Neurology
- Anesthesiology and Pain Medicine