Personalized orthodontics: Limitations and possibilities in orthodontic practice

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


Personalized medicine has garnered a tremendous amount of attention, yet has not even approached its potential in the provision of healthcare. This chapter includes synopses of orthodontic treatment guidelines and caveats for selected genetic conditions and syndromes. Multiple factors and processes contribute to the response to orthodontic treatment. Some patients exhibit unusual outcomes linked to or associated with polymorphic genes. Analysis of overall treatment response requires a systems analysis using informatics for integration of all relevant information. The influence of genetic factors on treatment outcome is studied and understood in quantitative terms. Conclusions from retrospective studies must be evaluated by prospective testing to truly evaluate their value in practice. Next Generation Sequencing and other types of genetic studies, and then their careful assessment in clinical trials for their relevance to diagnosis and treatment outcomes, are necessary to further the evidence base for the practice of orthodontics.

Original languageEnglish
Title of host publicationBiological Mechanisms of Tooth Movement
Subtitle of host publicationSecond Edition
Number of pages9
ISBN (Electronic)9781118916148
StatePublished - Jun 26 2015

Bibliographical note

Publisher Copyright:
© 2015 John Wiley & Sons, Ltd. All rights reserved.


  • Genetic factors
  • Next generation sequencing
  • Orthodontic treatment
  • Personalized medicine

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'Personalized orthodontics: Limitations and possibilities in orthodontic practice'. Together they form a unique fingerprint.

Cite this