pH-Sensitive mutagenic activity of ozone-treated 1,2-dimethylhydrazine in the Salmonella/microsome assay

Thomas M. Chambers, Gary R. Burleson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Treatment with ozone inactivates the mutagenicity of many carcinogens in aqueous solution. The colon carcinogen, 1,2-dimethylhydrazine (DMH) has been reported an exception; ozone treatment convenrts dimethylhydrazine from a non-mutagen into a mutagen. In the Salmonella/microsone assay, the mutagenicity of ozone-treated dimethylhydrazine was dependent on pH. The ozonation product was a strong mutagen in acidic but was not mutagenic in basic solution. The mutagenicity of the acidic ozonation product was inactivated by raising the pH of the solution. Unlike untreated dimethylhydrazine, its ozonation product in basic solution was not converted to a mutagen in this ozone-low pH system.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume94
Issue number1
DOIs
StatePublished - May 1982

Bibliographical note

Funding Information:
This work was supportedb y Large Bowel Cancer Grant No. CA 15957-08fr om the National Cancer Institute( USA) and by TelecommunicationIsn dustries,I nc., Copiague,N ew York. We wish to thank Dr. Morris Pollard for his encouragemenatn d support.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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