TY - JOUR
T1 - Pharmaceuticals in grocery market fish fillets by gas chromatography-mass spectrometry
AU - Mottaleb, Musavvir Arafat
AU - Stowe, Carly
AU - Johnson, Daniel R.
AU - Meziani, Mohammed J.
AU - Mottaleb, M. Abdul
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2016/6/10
Y1 - 2016/6/10
N2 - Occurrences of pharmaceuticals are evident in aquatic organisms. A reproducible gas chromatography-mass spectrometry (GC-MS) method using selected ion monitoring (SIM) has been used to determine the anti-histamine diphenhydramine (DPH), anti-anxiety diazepam (DZP), anti-seizure carbamazepine (CZP) drugs and their metabolites in grocery stores fish that were homogenized, extracted, pre-concentrated, cleaned up, and examined. Identifications of the compounds in extracts were obtained by comparing similar mass spectral features and retention properties with standards. Among nine frequently detected drugs, only DPH and DZP were observed and ranged from 0.61 to 6.21 and 1.99 to 16.57 ng/g, respectively, in fourteen fish species. These concentration values were lower than the environmental fish. Mean spike recoveries of analytes exceeded 75% with relative standard deviations (RSD) < 10%. The statistically-derived method detection limits (MDLs) for nine compounds ranged from 0.13 to 5.56 ng/g. Average surrogate recoveries were 80-85% with 4-9% RSD.
AB - Occurrences of pharmaceuticals are evident in aquatic organisms. A reproducible gas chromatography-mass spectrometry (GC-MS) method using selected ion monitoring (SIM) has been used to determine the anti-histamine diphenhydramine (DPH), anti-anxiety diazepam (DZP), anti-seizure carbamazepine (CZP) drugs and their metabolites in grocery stores fish that were homogenized, extracted, pre-concentrated, cleaned up, and examined. Identifications of the compounds in extracts were obtained by comparing similar mass spectral features and retention properties with standards. Among nine frequently detected drugs, only DPH and DZP were observed and ranged from 0.61 to 6.21 and 1.99 to 16.57 ng/g, respectively, in fourteen fish species. These concentration values were lower than the environmental fish. Mean spike recoveries of analytes exceeded 75% with relative standard deviations (RSD) < 10%. The statistically-derived method detection limits (MDLs) for nine compounds ranged from 0.13 to 5.56 ng/g. Average surrogate recoveries were 80-85% with 4-9% RSD.
KW - Diazepam
KW - Diphenhydramine
KW - Drugs
KW - Edible fish
KW - GC-MS
KW - Grocery stores
KW - Pharmaceuticals
UR - http://www.scopus.com/inward/record.url?scp=84930940191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930940191&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2015.06.003
DO - 10.1016/j.foodchem.2015.06.003
M3 - Article
C2 - 26213006
AN - SCOPUS:84930940191
SN - 0308-8146
VL - 190
SP - 529
EP - 536
JO - Food Chemistry
JF - Food Chemistry
ER -