Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties

Mark T.W. Ebbert, Wesley A. Beckstead, Timothy D. O'Connor, Mark J. Clement, David A. McClellan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.

Original languageEnglish
Pages (from-to)471-479
Number of pages9
JournalInternational Journal of Bioinformatics Research and Applications
Issue number4
StatePublished - Oct 2007


  • Amino acid properties
  • Bioinformatics
  • CYP2D6 gene
  • Pharmacogenomics
  • SNPs
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Clinical Biochemistry
  • Health Information Management


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