Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties

Mark T.W. Ebbert; Wesley A. Beckstead; Timothy D. O'Connor; Mark J. Clement; David A. McClellan

doi:10.1504/IJBRA.2007.015415

Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties

Mark T.W. Ebbert, Wesley A. Beckstead, Timothy D. O'Connor, Mark J. Clement, David A. McClellan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.

Original language	English
Pages (from-to)	471-479
Number of pages	9
Journal	International Journal of Bioinformatics Research and Applications
Volume	3
Issue number	4
DOIs	https://doi.org/10.1504/IJBRA.2007.015415
State	Published - Oct 2007

Keywords

Amino acid properties
Bioinformatics
CYP2D6 gene
Pharmacogenomics
SNPs
Single nucleotide polymorphisms

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Clinical Biochemistry
Health Information Management

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10.1504/IJBRA.2007.015415

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title = "Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties",

abstract = "The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.",

keywords = "Amino acid properties, Bioinformatics, CYP2D6 gene, Pharmacogenomics, SNPs, Single nucleotide polymorphisms",

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AU - Ebbert, Mark T.W.

AU - Beckstead, Wesley A.

AU - O'Connor, Timothy D.

AU - Clement, Mark J.

AU - McClellan, David A.

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AB - The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.

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KW - Bioinformatics

KW - CYP2D6 gene

KW - Pharmacogenomics

KW - SNPs

KW - Single nucleotide polymorphisms

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Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties

Abstract

Keywords

ASJC Scopus subject areas

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