Abstract
The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person's inability to metabolise specific drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 471-479 |
| Number of pages | 9 |
| Journal | International Journal of Bioinformatics Research and Applications |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2007 |
Keywords
- Amino acid properties
- Bioinformatics
- CYP2D6 gene
- Pharmacogenomics
- SNPs
- Single nucleotide polymorphisms
ASJC Scopus subject areas
- Biomedical Engineering
- Health Informatics
- Clinical Biochemistry
- Health Information Management
Fingerprint
Dive into the research topics of 'Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver