TY - JOUR
T1 - Pharmacokinetics of oxymorphone in cats
AU - Siao, K. T.
AU - Pypendop, B. H.
AU - Stanley, S. D.
AU - Ilkiw, J. E.
PY - 2011/12
Y1 - 2011/12
N2 - This study reports the pharmacokinetics of oxymorphone in spayed female cats after intravenous administration. Six healthy adult domestic shorthair spayed female cats were used. Oxymorphone (0.1mg/kg) was administered intravenously as a bolus. Blood samples were collected immediately prior to oxymorphone administration and at various times up to 480min following administration. Plasma oxymorphone concentrations were determined by liquid chromatography-mass spectrometry, and plasma oxymorphone concentration-time data were fitted to compartmental models. A three-compartment model, with input in and elimination from the central compartment, best described the disposition of oxymorphone following intravenous administration. The apparent volume of distribution of the central compartment and apparent volume of distribution at steady state [mean±SEM (range)] and the clearance and terminal half-life [harmonic mean±jackknife pseudo-SD (range)] were 1.1±0.2 (0.4-1.7) L/kg, 2.5±0.4 (2.4-4.4) L/kg, 26±7 (18-38) mL/min.kg, and 96±49 (62-277) min, respectively. The disposition of oxymorphone in cats is characterized by a moderate volume of distribution and a short terminal half-life.
AB - This study reports the pharmacokinetics of oxymorphone in spayed female cats after intravenous administration. Six healthy adult domestic shorthair spayed female cats were used. Oxymorphone (0.1mg/kg) was administered intravenously as a bolus. Blood samples were collected immediately prior to oxymorphone administration and at various times up to 480min following administration. Plasma oxymorphone concentrations were determined by liquid chromatography-mass spectrometry, and plasma oxymorphone concentration-time data were fitted to compartmental models. A three-compartment model, with input in and elimination from the central compartment, best described the disposition of oxymorphone following intravenous administration. The apparent volume of distribution of the central compartment and apparent volume of distribution at steady state [mean±SEM (range)] and the clearance and terminal half-life [harmonic mean±jackknife pseudo-SD (range)] were 1.1±0.2 (0.4-1.7) L/kg, 2.5±0.4 (2.4-4.4) L/kg, 26±7 (18-38) mL/min.kg, and 96±49 (62-277) min, respectively. The disposition of oxymorphone in cats is characterized by a moderate volume of distribution and a short terminal half-life.
UR - http://www.scopus.com/inward/record.url?scp=80054103585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054103585&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2885.2011.01271.x
DO - 10.1111/j.1365-2885.2011.01271.x
M3 - Article
C2 - 21323677
AN - SCOPUS:80054103585
SN - 0140-7783
VL - 34
SP - 594
EP - 598
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
IS - 6
ER -