Pharmacokinetics of the plant-derived κ-opioid hallucinogen salvinorin A in nonhuman primates

Matthew D. Schmidt, Mark S. Schmidt, Eduardo R. Butelman, Wayne W. Harding, Kevin Tidgewell, Daryl J. Murry, Mary Jeanne Kreek, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Salvinorin A, a potent hallucinogen isolated from the leaves of Salvia divinorum, has gained popularity among adolescents in the USA. No detailed study of the pharmacokinetics has been conducted in vivo. The present study investigates the in vivo pharmacokinetics of salvinorin A (0.032 mg/kg, i.v. bolus) in rhesus monkeys (n = 4, 2 male, 2 female). The elimination t 1/2 was rapid (56.6 ± 24.8 min) for all subjects. Pharmacokinetic differences (distribution t1/2, elimination t 1/2, and AUC) were observed between males and females, suggesting potential sex differences in its pharmacologic effects. Salvinorin B, the presumed major metabolite, is observed to accumulate ex vivo; however, in this study it never reached the limit of detection.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
Issue number3
StatePublished - Dec 1 2005


  • Hallucinogen
  • Salvia divinorum
  • Salvinorin A
  • κ-opioid

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Pharmacokinetics of the plant-derived κ-opioid hallucinogen salvinorin A in nonhuman primates'. Together they form a unique fingerprint.

Cite this