TY - JOUR
T1 - Pharmacokinetics of the plant-derived κ-opioid hallucinogen salvinorin A in nonhuman primates
AU - Schmidt, Matthew D.
AU - Schmidt, Mark S.
AU - Butelman, Eduardo R.
AU - Harding, Wayne W.
AU - Tidgewell, Kevin
AU - Murry, Daryl J.
AU - Kreek, Mary Jeanne
AU - Prisinzano, Thomas E.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Salvinorin A, a potent hallucinogen isolated from the leaves of Salvia divinorum, has gained popularity among adolescents in the USA. No detailed study of the pharmacokinetics has been conducted in vivo. The present study investigates the in vivo pharmacokinetics of salvinorin A (0.032 mg/kg, i.v. bolus) in rhesus monkeys (n = 4, 2 male, 2 female). The elimination t 1/2 was rapid (56.6 ± 24.8 min) for all subjects. Pharmacokinetic differences (distribution t1/2, elimination t 1/2, and AUC) were observed between males and females, suggesting potential sex differences in its pharmacologic effects. Salvinorin B, the presumed major metabolite, is observed to accumulate ex vivo; however, in this study it never reached the limit of detection.
AB - Salvinorin A, a potent hallucinogen isolated from the leaves of Salvia divinorum, has gained popularity among adolescents in the USA. No detailed study of the pharmacokinetics has been conducted in vivo. The present study investigates the in vivo pharmacokinetics of salvinorin A (0.032 mg/kg, i.v. bolus) in rhesus monkeys (n = 4, 2 male, 2 female). The elimination t 1/2 was rapid (56.6 ± 24.8 min) for all subjects. Pharmacokinetic differences (distribution t1/2, elimination t 1/2, and AUC) were observed between males and females, suggesting potential sex differences in its pharmacologic effects. Salvinorin B, the presumed major metabolite, is observed to accumulate ex vivo; however, in this study it never reached the limit of detection.
KW - Hallucinogen
KW - Salvia divinorum
KW - Salvinorin A
KW - κ-opioid
UR - http://www.scopus.com/inward/record.url?scp=26644453330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26644453330&partnerID=8YFLogxK
U2 - 10.1002/syn.20191
DO - 10.1002/syn.20191
M3 - Article
C2 - 16138318
AN - SCOPUS:26644453330
SN - 0887-4476
VL - 58
SP - 208
EP - 210
JO - Synapse
JF - Synapse
IS - 3
ER -