Pharmacologic management of heart failure: neurohormonal agents.

D. K. Moser

doi:10.1016/s0899-5885(18)30528-8

Pharmacologic management of heart failure: neurohormonal agents.

D. K. Moser

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Intense neurohormonal activation is characteristic of heart failure and contributes to the progression of ventricular dysfunction in this syndrome. Drugs that diminish neurohormonal arousal have a beneficial effect upon morbidity and mortality in chronic heart failure. The pathophysiology of neurohormonal activation in chronic heart failure is reviewed in this article to provide a basis for understanding intervention with agents that block the actions of the renin-angiotensin and sympathetic systems. Also covered is the description of the pharmacologic actions of these two classes of drugs and patient outcomes associated with their use.

Original language	English
Pages (from-to)	599-608
Number of pages	10
Journal	Critical Care Nursing Clinics of North America
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/s0899-5885(18)30528-8
State	Published - Dec 1993

Bibliographical note

Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

ASJC Scopus subject areas

Critical Care

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10.1016/s0899-5885(18)30528-8

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title = "Pharmacologic management of heart failure: neurohormonal agents.",

abstract = "Intense neurohormonal activation is characteristic of heart failure and contributes to the progression of ventricular dysfunction in this syndrome. Drugs that diminish neurohormonal arousal have a beneficial effect upon morbidity and mortality in chronic heart failure. The pathophysiology of neurohormonal activation in chronic heart failure is reviewed in this article to provide a basis for understanding intervention with agents that block the actions of the renin-angiotensin and sympathetic systems. Also covered is the description of the pharmacologic actions of these two classes of drugs and patient outcomes associated with their use.",

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AB - Intense neurohormonal activation is characteristic of heart failure and contributes to the progression of ventricular dysfunction in this syndrome. Drugs that diminish neurohormonal arousal have a beneficial effect upon morbidity and mortality in chronic heart failure. The pathophysiology of neurohormonal activation in chronic heart failure is reviewed in this article to provide a basis for understanding intervention with agents that block the actions of the renin-angiotensin and sympathetic systems. Also covered is the description of the pharmacologic actions of these two classes of drugs and patient outcomes associated with their use.

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Pharmacologic management of heart failure: neurohormonal agents.

Abstract

Bibliographical note

ASJC Scopus subject areas

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