Abstract
Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.
Original language | English |
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Pages (from-to) | 1143-1149 |
Number of pages | 7 |
Journal | Journal of Neurochemistry |
Volume | 41 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1983 |
Keywords
- 5‐Hydroxyindole metabolites
- Lysergic acid diethylamide
- Push‐pull perfusion
- Serotonin pools
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience