Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Mark S. Kleven, Linda P. Dwoskin, Sheldon B. Sparber

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.

Original languageEnglish
Pages (from-to)1143-1149
Number of pages7
JournalJournal of Neurochemistry
Volume41
Issue number4
DOIs
StatePublished - Apr 1983

Keywords

  • 5‐Hydroxyindole metabolites
  • Lysergic acid diethylamide
  • Push‐pull perfusion
  • Serotonin pools

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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