TY - JOUR
T1 - Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin
T2 - Analysis of Brain Perfusate From Conscious Rats
AU - Kleven, Mark S.
AU - Dwoskin, Linda P.
AU - Sparber, Sheldon B.
PY - 1983/4
Y1 - 1983/4
N2 - Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.
AB - Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.
KW - 5‐Hydroxyindole metabolites
KW - Lysergic acid diethylamide
KW - Push‐pull perfusion
KW - Serotonin pools
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U2 - 10.1111/j.1471-4159.1983.tb09064.x
DO - 10.1111/j.1471-4159.1983.tb09064.x
M3 - Article
C2 - 6194257
AN - SCOPUS:0020588982
SN - 0022-3042
VL - 41
SP - 1143
EP - 1149
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 4
ER -