Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Mark S. Kleven; Linda P. Dwoskin; Sheldon B. Sparber

doi:10.1111/j.1471-4159.1983.tb09064.x

Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Mark S. Kleven, Linda P. Dwoskin, Sheldon B. Sparber

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.

Original language	English
Pages (from-to)	1143-1149
Number of pages	7
Journal	Journal of Neurochemistry
Volume	41
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.1983.tb09064.x
State	Published - Apr 1983

Keywords

5‐Hydroxyindole metabolites
Lysergic acid diethylamide
Push‐pull perfusion
Serotonin pools

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1983.tb09064.x

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title = "Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats",

abstract = "Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.",

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AU - Dwoskin, Linda P.

AU - Sparber, Sheldon B.

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AB - Abstract: The serotonin reuptake inhibitor fluoxetine significantly reduced levels of endogenous 5‐hydroxyindoleacetic acid (5‐HIAA) in brain perfusate of rats implanted with push‐pull cannulas. This occurred in conjunction with its suppressant effect upon fixed‐ratio operant behavior. Behavior suppressed with the serotonin agonist lysergic acid diethylamide (LSD) occurred in conjunction with a reduction of 5‐HIAA only after 5‐HIAA was elevated, shortly before, by 5 mg/kg of the serotonin precursor 5‐hydroxytryptophan. Our data demonstrate the likely existence of multiple functional pools of serotonin in brain and support the notion that LSD preferentially affects a newly synthesized pool of this transmitter.

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KW - Lysergic acid diethylamide

KW - Push‐pull perfusion

KW - Serotonin pools

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Pharmacological Evidence for the Existence of Multiple Functional Pools of Brain Serotonin: Analysis of Brain Perfusate From Conscious Rats

Abstract

Keywords

ASJC Scopus subject areas

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