Pharmacological regulation of AP-1 transcription factor DNA binding activity

Keith R. Pennypacker, Jau Shyong Hong, Michael K. McMillian

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


The AP-1 transcription factor family consists of two groups of proteins, fos-related antigens (fra) and jun proteins. These transcription factors are usually expressed at low basal levels but they can be dramatically induced in a variety of cell types by many different stimuli, in which the quantity of AP-1 transcription factor and the DNA binding activity also rise. The quantity and DNA binding activity of transcription factors are not always at low levels. For example, early in brain development a high basal expression of AP-1 DNA binding activity exists. Similarly, adult rat adrenal gland contains high levels of AP-1 DNA binding activity whose regulation appears to be through post-translational modification (i.e., phosphorylation). Thus, AP- 1 DNA binding activity is modulated in a developmental and tissue-specific manner.

Original languageEnglish
Pages (from-to)475-478
Number of pages4
JournalFASEB Journal
Issue number8
StatePublished - 1994


  • CNS
  • adrenal gland
  • c-jun
  • cAMP responsive element binding protein
  • dopamine
  • fos-related antigen
  • kainate
  • nicotine

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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