Pharmacological studies of centrifugation-induced analgesia

Jon E. Sprague, Mark A. Suckow, Anne L. Fitzgerald, Cynthia F. Grigdesby, Robert L. Uetrecht, Roger P. Maickel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Subjecting rats to a brief period of centrifugal rotation produces a brief analgesia (1-2 min) that is similar to that produced by pretreatment with morphine. The effect of the morphine is blocked by naloxone, while that of the centrifugal rotation is only partially blocked by the same dose of naloxone. Cholinergic blocking agents such as scopolamine are also capable of partially blocking the rotational-induced analgesia. The combination of pretreatment with scopolamine plus naloxone is capable of completely blocking the rotational-induced analgesia, suggesting the involvement of both central cholinergic and endogenous opioid components.

Original languageEnglish
Pages (from-to)911-915
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number4
StatePublished - Dec 1993


  • Cholinergic factors
  • Endogenous opioids
  • Rotation-induced analgesia

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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