Pharmacology of procaine in the horse: a preliminary report.

T. Tobin, J. W. Blake, C. Y. Tai, S. Arnett

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Rapid intravenous injection of 1 g of procaine hydrochloride in Thoroughbred mares produced variable signs of central nervous system excitation for as long as 4 minutes. Plasma concentrations of procaine were similarly variable and transient, decreasing with a half-life of approximately 25 minutes. In vitro, plasma from freshly collected equine blood hydrolyzed procaine with a half-life of approximately 7.5 minutes. This hydrolysis was apparently due to plasma esterases. Penicillin, when added free or complexed as procaine-penicillin, did not protect procaine against hydrolysis by these plasma esterases at pH 7.4.

Original languageEnglish
Pages (from-to)1107-1110
Number of pages4
JournalAmerican Journal of Veterinary Research
Issue number9
StatePublished - Sep 1976

ASJC Scopus subject areas

  • General Veterinary


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