Abstract
Rapid intravenous injection of 1 g of procaine hydrochloride in Thoroughbred mares produced variable signs of central nervous system excitation for as long as 4 minutes. Plasma concentrations of procaine were similarly variable and transient, decreasing with a half-life of approximately 25 minutes. In vitro, plasma from freshly collected equine blood hydrolyzed procaine with a half-life of approximately 7.5 minutes. This hydrolysis was apparently due to plasma esterases. Penicillin, when added free or complexed as procaine-penicillin, did not protect procaine against hydrolysis by these plasma esterases at pH 7.4.
Original language | English |
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Pages (from-to) | 1107-1110 |
Number of pages | 4 |
Journal | American Journal of Veterinary Research |
Volume | 37 |
Issue number | 9 |
State | Published - Sep 1976 |
ASJC Scopus subject areas
- General Veterinary