Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department

Blake Robbins; Lars Almassalkhi; Regan Baum; Matthew Blackburn; Jason Davis; Lindsey Edwards; Garrett Hile; William Olney; Kyle Weant; Elise Metts

doi:10.1016/j.ajem.2024.12.004

Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department

Blake Robbins, Lars Almassalkhi, Regan Baum, Matthew Blackburn, Jason Davis, Lindsey Edwards, Garrett Hile, William Olney, Kyle Weant, Elise Metts

Research output: Contribution to journal › Article › peer-review

Abstract

Traumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.

Original language	English
Pages (from-to)	78-84
Number of pages	7
Journal	American Journal of Emergency Medicine
Volume	89
DOIs	https://doi.org/10.1016/j.ajem.2024.12.004
State	E-pub ahead of print - Dec 8 2024

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Robbins, B., Almassalkhi, L., Baum, R., Blackburn, M., Davis, J., Edwards, L., Hile, G., Olney, W., Weant, K., & Metts, E. (2024). Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department. American Journal of Emergency Medicine, 89, 78-84. Advance online publication. https://doi.org/10.1016/j.ajem.2024.12.004

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abstract = "Traumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.",

author = "Blake Robbins and Lars Almassalkhi and Regan Baum and Matthew Blackburn and Jason Davis and Lindsey Edwards and Garrett Hile and William Olney and Kyle Weant and Elise Metts",

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AU - Robbins, Blake

AU - Almassalkhi, Lars

AU - Baum, Regan

AU - Blackburn, Matthew

AU - Davis, Jason

AU - Edwards, Lindsey

AU - Hile, Garrett

AU - Olney, William

AU - Weant, Kyle

AU - Metts, Elise

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N2 - Traumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.

AB - Traumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.

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DO - 10.1016/j.ajem.2024.12.004

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EP - 84

JO - American Journal of Emergency Medicine

JF - American Journal of Emergency Medicine

ER -

Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department

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