TY - JOUR
T1 - Pharmacotherapy regimens among patients with posttraumatic stress disorder and mild traumatic brain injury
AU - Morgan, Meghan
AU - Lockwood, Anna
AU - Steinke, Doug
AU - Schleenbaker, Randal
AU - Botts, Sheila
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Objective: The purpose of this study was to determine if veterans with posttraumatic stress disorder (PTSD) and mild traumatic brain injury (TBI) are treated differently pharmacologically than patients with PTSD alone. Methods: A retrospective evaluation of PTSD pharmacotherapy of Operation Enduring Freedom/Operation Iraqi Freedom veterans with PTSD (N=707) was conducted between April 1, 2007, and March 31, 2009. A total of 45 veterans had suffered a mild TBI. Results: Compared with the patients with PTSD alone, the patients with PTSD and TBI were more likely to be prescribed an antidepressant (p<.001), a sedative-hypnotic (p<.001), or an antipsychotic (p= .024). The patients with TBI were also significantly more likely toreceive psychotropic polypharmacy (p=.001) and to receive higher doses of psychiatric medications (p=.03). Conclusions: The differences in drug therapy found in this study may indicate that patients with TBI and PTSD respond differently to treatment than patients with PTSD alone.
AB - Objective: The purpose of this study was to determine if veterans with posttraumatic stress disorder (PTSD) and mild traumatic brain injury (TBI) are treated differently pharmacologically than patients with PTSD alone. Methods: A retrospective evaluation of PTSD pharmacotherapy of Operation Enduring Freedom/Operation Iraqi Freedom veterans with PTSD (N=707) was conducted between April 1, 2007, and March 31, 2009. A total of 45 veterans had suffered a mild TBI. Results: Compared with the patients with PTSD alone, the patients with PTSD and TBI were more likely to be prescribed an antidepressant (p<.001), a sedative-hypnotic (p<.001), or an antipsychotic (p= .024). The patients with TBI were also significantly more likely toreceive psychotropic polypharmacy (p=.001) and to receive higher doses of psychiatric medications (p=.03). Conclusions: The differences in drug therapy found in this study may indicate that patients with TBI and PTSD respond differently to treatment than patients with PTSD alone.
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U2 - 10.1176/appi.ps.201000531
DO - 10.1176/appi.ps.201000531
M3 - Article
C2 - 22302339
AN - SCOPUS:84857679010
SN - 1075-2730
VL - 63
SP - 182
EP - 185
JO - Psychiatric Services
JF - Psychiatric Services
IS - 2
ER -