Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

Ronald G. Crystal; Edward Hirschowitz; Michael Lieberman; John Daly; Elias Kazam; Claudia Henschke; David Yankelevitz; Nancy Kemeny; Roy Silverstein; Akihiko Ohwada; Thomas Russi; Andrea Mastrangeli; Abraham Sanders; Joseph Cooke; Ben Gary Harvey

doi:10.1089/hum.1997.8.8-985

Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

Ronald G. Crystal
, Edward Hirschowitz
, Michael Lieberman
, John Daly
, Elias Kazam
, Claudia Henschke
, David Yankelevitz
, Nancy Kemeny
, Roy Silverstein
, Akihiko Ohwada
, Thomas Russi
, Andrea Mastrangeli
, Abraham Sanders
, Joseph Cooke
, Ben Gary Harvey

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Original language	English
Pages (from-to)	985-1001
Number of pages	17
Journal	Human Gene Therapy
Volume	8
Issue number	8
DOIs	https://doi.org/10.1089/hum.1997.8.8-985
State	Published - May 20 1997

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics

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Crystal, R. G., Hirschowitz, E., Lieberman, M., Daly, J., Kazam, E., Henschke, C., Yankelevitz, D., Kemeny, N., Silverstein, R., Ohwada, A., Russi, T., Mastrangeli, A., Sanders, A., Cooke, J., & Harvey, B. G. (1997). Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Human Gene Therapy, 8(8), 985-1001. https://doi.org/10.1089/hum.1997.8.8-985

Crystal, Ronald G. ; Hirschowitz, Edward ; Lieberman, Michael et al. / Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. In: Human Gene Therapy. 1997 ; Vol. 8, No. 8. pp. 985-1001.

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title = "Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine",

author = "Crystal, \{Ronald G.\} and Edward Hirschowitz and Michael Lieberman and John Daly and Elias Kazam and Claudia Henschke and David Yankelevitz and Nancy Kemeny and Roy Silverstein and Akihiko Ohwada and Thomas Russi and Andrea Mastrangeli and Abraham Sanders and Joseph Cooke and Harvey, \{Ben Gary\}",

year = "1997",

month = may,

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doi = "10.1089/hum.1997.8.8-985",

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Crystal, RG, Hirschowitz, E, Lieberman, M, Daly, J, Kazam, E, Henschke, C, Yankelevitz, D, Kemeny, N, Silverstein, R, Ohwada, A, Russi, T, Mastrangeli, A, Sanders, A, Cooke, J & Harvey, BG 1997, 'Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine', Human Gene Therapy, vol. 8, no. 8, pp. 985-1001. https://doi.org/10.1089/hum.1997.8.8-985

Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. / Crystal, Ronald G.; Hirschowitz, Edward; Lieberman, Michael et al.
In: Human Gene Therapy, Vol. 8, No. 8, 20.05.1997, p. 985-1001.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

AU - Crystal, Ronald G.

AU - Hirschowitz, Edward

AU - Lieberman, Michael

AU - Daly, John

AU - Kazam, Elias

AU - Henschke, Claudia

AU - Yankelevitz, David

AU - Kemeny, Nancy

AU - Silverstein, Roy

AU - Ohwada, Akihiko

AU - Russi, Thomas

AU - Mastrangeli, Andrea

AU - Sanders, Abraham

AU - Cooke, Joseph

AU - Harvey, Ben Gary

PY - 1997/5/20

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DO - 10.1089/hum.1997.8.8-985

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AN - SCOPUS:16944365155

SN - 1043-0342

VL - 8

SP - 985

EP - 1001

JO - Human Gene Therapy

JF - Human Gene Therapy

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ER -

Crystal RG, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C et al. Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Human Gene Therapy. 1997 May 20;8(8):985-1001. doi: 10.1089/hum.1997.8.8-985

Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

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