Phenotype Control techniques for Boolean gene regulatory networks

Daniel Plaugher, David Murrugarra

Research output: Contribution to journalReview articlepeer-review


Modeling cell signal transduction pathways via Boolean networks (BNs) has become an established method for analyzing intracellular communications over the last few decades. What’s more, BNs provide a course-grained approach, not only to understanding molecular communications, but also for targeting pathway components that alter the long-term outcomes of the system. This has come to be known as phenotype control theory. In this review we study the interplay of various approaches for controlling gene regulatory networks such as: algebraic methods, control kernel, feedback vertex set, and stable motifs. The study will also include comparative discussion between the methods, using an established cancer model of T-Cell Large Granular Lymphocyte Leukemia. Further, we explore possible options for making the control search more efficient using reduction and modularity. Finally, we will include challenges presented such as the complexity and the availability of software for implementing each of these control techniques.

Original languageEnglish
Article number89
JournalBulletin of Mathematical Biology
Issue number10
StatePublished - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Society for Mathematical Biology.


  • Boolean networks
  • Discrete dynamical systems
  • Network dynamics
  • Phenotype control theory
  • Regulatory networks

ASJC Scopus subject areas

  • General Neuroscience
  • Immunology
  • General Mathematics
  • General Biochemistry, Genetics and Molecular Biology
  • General Environmental Science
  • Pharmacology
  • General Agricultural and Biological Sciences
  • Computational Theory and Mathematics


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