TY - JOUR
T1 - Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2
AU - Loftin, Charles D.
AU - Tiano, Howard F.
AU - Langenbach, Robert
PY - 2002/8
Y1 - 2002/8
N2 - The development of mice deficient in either cyclooxygenase-1 (COX-1) or COX-2, as well as mice deficient in both COX isoforms, has provided models to elucidate the physiological and pathophysiological roles of these enzymes. The findings obtained with the COX-deficient mice suggest that COX-2 may be more important than COX-1 for supplying prostaglandins (PGs) to maintain tissue homeostasis. Furthermore, both isoforms may be involved in the development of diseases, such as inflammation and cancer. Therefore, the contribution of each isoform to the prevention or development of disease is more complex than originally described. Studies with the COX-deficient mice suggest that in addition to COX-2-selective inhibition, therapeutic advances may also be achieved with COX-1-selective inhibitors which lack gastrointestinal side effects.
AB - The development of mice deficient in either cyclooxygenase-1 (COX-1) or COX-2, as well as mice deficient in both COX isoforms, has provided models to elucidate the physiological and pathophysiological roles of these enzymes. The findings obtained with the COX-deficient mice suggest that COX-2 may be more important than COX-1 for supplying prostaglandins (PGs) to maintain tissue homeostasis. Furthermore, both isoforms may be involved in the development of diseases, such as inflammation and cancer. Therefore, the contribution of each isoform to the prevention or development of disease is more complex than originally described. Studies with the COX-deficient mice suggest that in addition to COX-2-selective inhibition, therapeutic advances may also be achieved with COX-1-selective inhibitors which lack gastrointestinal side effects.
KW - Cancer
KW - Cyclooxygenase
KW - Inflammation
KW - Isoform
KW - Mice
KW - Reproduction
UR - http://www.scopus.com/inward/record.url?scp=0036669406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036669406&partnerID=8YFLogxK
U2 - 10.1016/S0090-6980(02)00028-X
DO - 10.1016/S0090-6980(02)00028-X
M3 - Article
C2 - 12432917
AN - SCOPUS:0036669406
SN - 0090-6980
VL - 68-69
SP - 177
EP - 185
JO - Prostaglandins and Other Lipid Mediators
JF - Prostaglandins and Other Lipid Mediators
ER -