Abstract
Phenotypic and functional properties of B lymphocytes from individual young and old mice of different inbred strains were studied. B lymphocyte subpopulation defined by the ratios of the densities of cell surface IgM and IgD were found to be altered with age. However, such alterations in B cell subsets were found only in 30-40% of the old mice. B cell mitogenic responses to anti-μ and anti-Lyb2 antibodies were decreased in a majority of DBA/2 mice. Proliferative responses to LPS and antiμ were reduced only in a minority of CBA/Ca mice but there was a very good correlation in the responsiveness of the old mice to LPS and anti-μ. The anomalous properties of the individual old mice of these inbred strains may be due to a heterogeneity in the effects of aging or due to environmental influences.
| Original language | English |
|---|---|
| Pages (from-to) | 223-241 |
| Number of pages | 19 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 51 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 15 1990 |
Bibliographical note
Funding Information:*This work was supported in part by the grants AI21490, AG05731 and the PSP funds of the University of Kentucky: **SB is a recipient of a career research development award (AG00422). tTo whom correspondence should be addressed at: Room 205, Sanders-Brown Building, University of Kentucky, Lexington, KY 40536-0230, U.S.A.
Keywords
- Aging
- B lymphocytes
- Immune function
- Inbred strains of mice
- Lymphocyte activation
- Lymphocyte surface molecules
ASJC Scopus subject areas
- Aging
- Developmental Biology