Phenotypic and functional properties of B lymphocytes from aged mice

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Phenotypic and functional properties of B lymphocytes from individual young and old mice of different inbred strains were studied. B lymphocyte subpopulation defined by the ratios of the densities of cell surface IgM and IgD were found to be altered with age. However, such alterations in B cell subsets were found only in 30-40% of the old mice. B cell mitogenic responses to anti-μ and anti-Lyb2 antibodies were decreased in a majority of DBA/2 mice. Proliferative responses to LPS and antiμ were reduced only in a minority of CBA/Ca mice but there was a very good correlation in the responsiveness of the old mice to LPS and anti-μ. The anomalous properties of the individual old mice of these inbred strains may be due to a heterogeneity in the effects of aging or due to environmental influences.

Original languageEnglish
Pages (from-to)223-241
Number of pages19
JournalMechanisms of Ageing and Development
Issue number3
StatePublished - Feb 15 1990

Bibliographical note

Funding Information:
*This work was supported in part by the grants AI21490, AG05731 and the PSP funds of the University of Kentucky: **SB is a recipient of a career research development award (AG00422). tTo whom correspondence should be addressed at: Room 205, Sanders-Brown Building, University of Kentucky, Lexington, KY 40536-0230, U.S.A.


  • Aging
  • B lymphocytes
  • Immune function
  • Inbred strains of mice
  • Lymphocyte activation
  • Lymphocyte surface molecules

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


Dive into the research topics of 'Phenotypic and functional properties of B lymphocytes from aged mice'. Together they form a unique fingerprint.

Cite this