TY - JOUR
T1 - Phenytoin and Membrane Fluidity in Myotonic Dystrophy
AU - Roses, Allen D.
AU - Butterfield, D. Allan
AU - Appel, Stanley H.
AU - Chestnut, Donald B.
PY - 1975/8
Y1 - 1975/8
N2 - Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin (formerly diphenylhydantoin) “normalizes” fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.
AB - Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin (formerly diphenylhydantoin) “normalizes” fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.
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U2 - 10.1001/archneur.1975.00490500055006
DO - 10.1001/archneur.1975.00490500055006
M3 - Article
C2 - 168843
AN - SCOPUS:0016593519
SN - 0003-9942
VL - 32
SP - 535
EP - 538
JO - Archives of Neurology
JF - Archives of Neurology
IS - 8
ER -