Phenytoin and Membrane Fluidity in Myotonic Dystrophy

Allen D. Roses, D. Allan Butterfield, Stanley H. Appel, Donald B. Chestnut

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin (formerly diphenylhydantoin) “normalizes” fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.

Original languageEnglish
Pages (from-to)535-538
Number of pages4
JournalArchives of Neurology
Issue number8
StatePublished - Aug 1975

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


Dive into the research topics of 'Phenytoin and Membrane Fluidity in Myotonic Dystrophy'. Together they form a unique fingerprint.

Cite this