Abstract
Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo. Phospholipase D has been found on the Golgi apparatus and is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking. Moreover, the product of phospholipase D activity, phosphatidic acid, as well as its degradation product diacylglycerol, have been implicated in vesicle fission and fusion events. Here we summarize recent advances in the understanding of the role of phospholipase D at the Golgi apparatus.
Original language | English |
---|---|
Pages (from-to) | 876-880 |
Number of pages | 5 |
Journal | Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids |
Volume | 1791 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2009 |
Bibliographical note
Funding Information:The authors like to thank Sunandini Sridhar for very helpful suggestions with the manuscript. CR was supported by a Fellowship from the New York State Department of Health (C021327); this work was supported by a National Institutes of Health grants (DK21860) to DS and (CA096496 and GM050388) to AJM.
Keywords
- Golgi apparatus
- Phosphatidic acid
- Phospholipase D
- Vesicular trafficking
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology