Phospholipase D in the Golgi apparatus

Christian Riebeling; Andrew J. Morris; Dennis Shields

doi:10.1016/j.bbalip.2009.04.003

Phospholipase D in the Golgi apparatus

Christian Riebeling, Andrew J. Morris, Dennis Shields

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo. Phospholipase D has been found on the Golgi apparatus and is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking. Moreover, the product of phospholipase D activity, phosphatidic acid, as well as its degradation product diacylglycerol, have been implicated in vesicle fission and fusion events. Here we summarize recent advances in the understanding of the role of phospholipase D at the Golgi apparatus.

Original language	English
Pages (from-to)	876-880
Number of pages	5
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1791
Issue number	9
DOIs	https://doi.org/10.1016/j.bbalip.2009.04.003
State	Published - Sep 2009

Bibliographical note

Funding Information:
The authors like to thank Sunandini Sridhar for very helpful suggestions with the manuscript. CR was supported by a Fellowship from the New York State Department of Health (C021327); this work was supported by a National Institutes of Health grants (DK21860) to DS and (CA096496 and GM050388) to AJM.

Keywords

Golgi apparatus
Phosphatidic acid
Phospholipase D
Vesicular trafficking

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.bbalip.2009.04.003

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abstract = "Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo. Phospholipase D has been found on the Golgi apparatus and is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking. Moreover, the product of phospholipase D activity, phosphatidic acid, as well as its degradation product diacylglycerol, have been implicated in vesicle fission and fusion events. Here we summarize recent advances in the understanding of the role of phospholipase D at the Golgi apparatus.",

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AU - Morris, Andrew J.

AU - Shields, Dennis

N1 - Funding Information: The authors like to thank Sunandini Sridhar for very helpful suggestions with the manuscript. CR was supported by a Fellowship from the New York State Department of Health (C021327); this work was supported by a National Institutes of Health grants (DK21860) to DS and (CA096496 and GM050388) to AJM.

PY - 2009/9

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N2 - Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo. Phospholipase D has been found on the Golgi apparatus and is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking. Moreover, the product of phospholipase D activity, phosphatidic acid, as well as its degradation product diacylglycerol, have been implicated in vesicle fission and fusion events. Here we summarize recent advances in the understanding of the role of phospholipase D at the Golgi apparatus.

AB - Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo. Phospholipase D has been found on the Golgi apparatus and is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking. Moreover, the product of phospholipase D activity, phosphatidic acid, as well as its degradation product diacylglycerol, have been implicated in vesicle fission and fusion events. Here we summarize recent advances in the understanding of the role of phospholipase D at the Golgi apparatus.

KW - Golgi apparatus

KW - Phosphatidic acid

KW - Phospholipase D

KW - Vesicular trafficking

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JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

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Phospholipase D in the Golgi apparatus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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