Phospholipase D structure and regulation

Michael A. Frohman, Andrew J. Morris

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)127-140
Number of pages14
JournalChemistry and Physics of Lipids
Issue number1-2
StatePublished - Apr 1999

Bibliographical note

Funding Information:
The authors thank laboratory members for critical reading of the manuscript. This work was supported by grants from the NIH to AIM (GM50388) and MAF (GM54813).


  • ARF
  • PLD1
  • PLD2
  • Phospholipase D
  • Protein kinase C
  • Rho

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology


Dive into the research topics of 'Phospholipase D structure and regulation'. Together they form a unique fingerprint.

Cite this