Phosphorylation Regulation of Hedgehog Signaling

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.

Original languageEnglish
Title of host publicationVitamins and Hormones
Number of pages20
StatePublished - 2012

Publication series

NameVitamins and Hormones
ISSN (Print)0083-6729

Bibliographical note

Funding Information:
J. Jia is supported by the National Institutes of Health and the American Heart Association. The author thanks Jennifer Rogers for critically reviewing the manuscript.


  • CK1
  • CK2
  • Ci/Gli
  • Fu
  • GSK3
  • Hh
  • PKA
  • PP2A
  • PP4
  • Phosphorylation
  • Signal Transduction
  • Smo

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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