The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.
|Title of host publication||Vitamins and Hormones|
|Number of pages||20|
|State||Published - 2012|
|Name||Vitamins and Hormones|
Bibliographical noteFunding Information:
J. Jia is supported by the National Institutes of Health and the American Heart Association. The author thanks Jennifer Rogers for critically reviewing the manuscript.
- Signal Transduction
ASJC Scopus subject areas