Abstract
The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.
Original language | English |
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Title of host publication | Vitamins and Hormones |
Pages | 253-272 |
Number of pages | 20 |
DOIs | |
State | Published - 2012 |
Publication series
Name | Vitamins and Hormones |
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Volume | 88 |
ISSN (Print) | 0083-6729 |
Bibliographical note
Funding Information:J. Jia is supported by the National Institutes of Health and the American Heart Association. The author thanks Jennifer Rogers for critically reviewing the manuscript.
Keywords
- CK1
- CK2
- Ci/Gli
- Fu
- GSK3
- Hh
- PKA
- PP2A
- PP4
- Phosphorylation
- Signal Transduction
- Smo
ASJC Scopus subject areas
- Physiology
- Endocrinology