Phosphorylation Regulation of Hedgehog Signaling

Jianhang Jia

doi:10.1016/B978-0-12-394622-5.00011-0

Phosphorylation Regulation of Hedgehog Signaling

Jianhang Jia

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.

Original language	English
Title of host publication	Vitamins and Hormones
Pages	253-272
Number of pages	20
DOIs	https://doi.org/10.1016/B978-0-12-394622-5.00011-0
State	Published - 2012

Publication series

Name	Vitamins and Hormones
Volume	88
ISSN (Print)	0083-6729

Bibliographical note

Funding Information:
J. Jia is supported by the National Institutes of Health and the American Heart Association. The author thanks Jennifer Rogers for critically reviewing the manuscript.

Funding

J. Jia is supported by the National Institutes of Health and the American Heart Association. The author thanks Jennifer Rogers for critically reviewing the manuscript.

Funders	Funder number
National Institutes of Health (NIH)
American Heart Association

Keywords

CK1
CK2
Ci/Gli
Fu
GSK3
Hh
PKA
PP2A
PP4
Phosphorylation
Signal Transduction
Smo

ASJC Scopus subject areas

Physiology
Endocrinology

Access to Document

10.1016/B978-0-12-394622-5.00011-0

Cite this

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title = "Phosphorylation Regulation of Hedgehog Signaling",

abstract = "The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.",

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KW - Hh

KW - PKA

KW - PP2A

KW - PP4

KW - Phosphorylation

KW - Signal Transduction

KW - Smo

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Phosphorylation Regulation of Hedgehog Signaling

Abstract

Publication series

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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