Phosphorylation Regulation of Hedgehog Signaling

Jianhang Jia

doi:10.1016/B978-0-12-394622-5.00011-0

Phosphorylation Regulation of Hedgehog Signaling

Jianhang Jia

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.

Original language	English
Title of host publication	Vitamins and Hormones
Pages	253-272
Number of pages	20
DOIs	https://doi.org/10.1016/B978-0-12-394622-5.00011-0
State	Published - 2012

Publication series

Name	Vitamins and Hormones
Volume	88
ISSN (Print)	0083-6729

Bibliographical note

Funding Information:
J. Jia is supported by the National Institutes of Health and the American Heart Association. The author thanks Jennifer Rogers for critically reviewing the manuscript.

Keywords

CK1
CK2
Ci/Gli
Fu
GSK3
Hh
PKA
PP2A
PP4
Phosphorylation
Signal Transduction
Smo

ASJC Scopus subject areas

Physiology
Endocrinology

Access to Document

10.1016/B978-0-12-394622-5.00011-0

Cite this

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title = "Phosphorylation Regulation of Hedgehog Signaling",

abstract = "The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway leads to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves during the phosphorylation/dephosphorylation of players in the Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.",

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KW - Fu

KW - GSK3

KW - Hh

KW - PKA

KW - PP2A

KW - PP4

KW - Phosphorylation

KW - Signal Transduction

KW - Smo

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Phosphorylation Regulation of Hedgehog Signaling

Abstract

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Bibliographical note

Keywords

ASJC Scopus subject areas

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