Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents

Achmad N. Hidayatullah; Erin Wachter; David K. Heidary; Sean Parkin; Edith C. Glazer

doi:10.1021/ic5017164

Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents

Achmad N. Hidayatullah, Erin Wachter, David K. Heidary, Sean Parkin, Edith C. Glazer

Chemistry

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.

Original language	English
Pages (from-to)	10030-10032
Number of pages	3
Journal	Inorganic Chemistry
Volume	53
Issue number	19
DOIs	https://doi.org/10.1021/ic5017164
State	Published - Oct 6 2014

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Publisher Copyright:
© 2014 American Chemical Society.

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/ic5017164

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abstract = "Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.",

author = "Hidayatullah, {Achmad N.} and Erin Wachter and Heidary, {David K.} and Sean Parkin and Glazer, {Edith C.}",

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AU - Hidayatullah, Achmad N.

AU - Wachter, Erin

AU - Heidary, David K.

AU - Parkin, Sean

AU - Glazer, Edith C.

PY - 2014/10/6

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Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents

Abstract

Bibliographical note

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UN SDGs

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