Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents

Achmad N. Hidayatullah, Erin Wachter, David K. Heidary, Sean Parkin, Edith C. Glazer

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.

Original languageEnglish
Pages (from-to)10030-10032
Number of pages3
JournalInorganic Chemistry
Volume53
Issue number19
DOIs
StatePublished - Oct 6 2014

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents'. Together they form a unique fingerprint.

Cite this