TY - JOUR
T1 - Physical activity is associated with cognitive processing speed in persons with multiple sclerosis
AU - Sandroff, Brian M.
AU - Dlugonski, Deirdre
AU - Pilutti, Lara A.
AU - Pula, John H.
AU - Benedict, Ralph H.B.
AU - Motl, Robert W.
PY - 2014/1
Y1 - 2014/1
N2 - The impairment of cognitive processing speed is common, disabling, and poorly managed in multiple sclerosis (MS). This study examined the association between objectively-measured physical activity and cognitive processing speed (CPS) in a large sample of persons with MS. Patients (N=212) underwent two valid neuropsychological tests of CPS, completed the Timed 25-Foot Walk (T25FW), and wore an ActiGraph model GT3X accelerometer during the waking hours of a 7-day period for objectively measuring physical activity as steps/day. Physical activity was significantly associated with CPS (r=.39, p<.01), even when controlling for age, sex, and education (pr=.26, p<.01). This association was attenuated, but still significant after further controlling for T25FW performance (pr=.13, p=.03). Physical activity behavior is positively and independently, albeit weakly, associated with CPS in persons with MS, and may play an important role in managing this aspect of cognition as it does in other outcomes in MS.
AB - The impairment of cognitive processing speed is common, disabling, and poorly managed in multiple sclerosis (MS). This study examined the association between objectively-measured physical activity and cognitive processing speed (CPS) in a large sample of persons with MS. Patients (N=212) underwent two valid neuropsychological tests of CPS, completed the Timed 25-Foot Walk (T25FW), and wore an ActiGraph model GT3X accelerometer during the waking hours of a 7-day period for objectively measuring physical activity as steps/day. Physical activity was significantly associated with CPS (r=.39, p<.01), even when controlling for age, sex, and education (pr=.26, p<.01). This association was attenuated, but still significant after further controlling for T25FW performance (pr=.13, p=.03). Physical activity behavior is positively and independently, albeit weakly, associated with CPS in persons with MS, and may play an important role in managing this aspect of cognition as it does in other outcomes in MS.
KW - Accelerometer
KW - Cognition
KW - Cognitive processing speed
KW - Multiple sclerosis
KW - Physical activity
KW - Walking performance
UR - http://www.scopus.com/inward/record.url?scp=84884291170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884291170&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2013.04.003
DO - 10.1016/j.msard.2013.04.003
M3 - Article
AN - SCOPUS:84884291170
SN - 2211-0348
VL - 3
SP - 123
EP - 128
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
IS - 1
ER -