TY - JOUR
T1 - Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity
AU - Fabbrini, Elisa
AU - Tiemann Luecking, Courtney
AU - Love-Gregory, Latisha
AU - Okunade, Adewole L.
AU - Yoshino, Mihoko
AU - Fraterrigo, Gemma
AU - Patterson, Bruce W.
AU - Klein, Samuel
N1 - Publisher Copyright:
© 2016 AGA Institute.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.
AB - Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.
KW - Fatty Acid Oxidation
KW - Overweight
KW - VLDL
KW - apoB100
UR - http://www.scopus.com/inward/record.url?scp=84952714964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952714964&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2015.09.003
DO - 10.1053/j.gastro.2015.09.003
M3 - Article
C2 - 26376348
AN - SCOPUS:84952714964
SN - 0016-5085
VL - 150
SP - 79-81.e2
JO - Gastroenterology
JF - Gastroenterology
IS - 1
ER -