Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Elisa Fabbrini; Courtney Tiemann Luecking; Latisha Love-Gregory; Adewole L. Okunade; Mihoko Yoshino; Gemma Fraterrigo; Bruce W. Patterson; Samuel Klein

doi:10.1053/j.gastro.2015.09.003

Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Elisa Fabbrini, Courtney Tiemann Luecking, Latisha Love-Gregory, Adewole L. Okunade, Mihoko Yoshino, Gemma Fraterrigo, Bruce W. Patterson, Samuel Klein

Dietetics and Human Nutrition

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

Original language	English
Pages (from-to)	79-81.e2
Journal	Gastroenterology
Volume	150
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2015.09.003
State	Published - Jan 1 2016

Bibliographical note

Funding Information:
The authors thank Emily Lake for assistance in recruiting the study subjects, Freida Custodio, and Jennifer Shew for technical assistance, Melisa Moore, Kathryn Gratza and the staff of the Clinical Research Unit for help in performing the studies, and the study subjects for their participation. Dr. Samuel Klein is the guarantor of this work, had full access to all the data, and takes full responsibility for the integrity of data and the accuracy of data analysis. This study was supported by National Institutes of Health grants UL1 RR024992 (Clinical Translational Science Award), DK 56341 (Nutrition and Obesity Research Center), DK 20579 (Diabetes Research Center), DK 37948, a grant from the Longer Life Foundation, and support from the Kilo Foundation.

Publisher Copyright:
© 2016 AGA Institute.

Keywords

Fatty Acid Oxidation
Overweight
VLDL
apoB100

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1053/j.gastro.2015.09.003

Cite this

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title = "Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity",

abstract = "Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.",

keywords = "Fatty Acid Oxidation, Overweight, VLDL, apoB100",

author = "Elisa Fabbrini and {Tiemann Luecking}, Courtney and Latisha Love-Gregory and Okunade, {Adewole L.} and Mihoko Yoshino and Gemma Fraterrigo and Patterson, {Bruce W.} and Samuel Klein",

note = "Funding Information: The authors thank Emily Lake for assistance in recruiting the study subjects, Freida Custodio, and Jennifer Shew for technical assistance, Melisa Moore, Kathryn Gratza and the staff of the Clinical Research Unit for help in performing the studies, and the study subjects for their participation. Dr. Samuel Klein is the guarantor of this work, had full access to all the data, and takes full responsibility for the integrity of data and the accuracy of data analysis. This study was supported by National Institutes of Health grants UL1 RR024992 (Clinical Translational Science Award), DK 56341 (Nutrition and Obesity Research Center), DK 20579 (Diabetes Research Center), DK 37948, a grant from the Longer Life Foundation, and support from the Kilo Foundation. Publisher Copyright: {\textcopyright} 2016 AGA Institute.",

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AU - Yoshino, Mihoko

AU - Fraterrigo, Gemma

AU - Patterson, Bruce W.

AU - Klein, Samuel

N1 - Funding Information: The authors thank Emily Lake for assistance in recruiting the study subjects, Freida Custodio, and Jennifer Shew for technical assistance, Melisa Moore, Kathryn Gratza and the staff of the Clinical Research Unit for help in performing the studies, and the study subjects for their participation. Dr. Samuel Klein is the guarantor of this work, had full access to all the data, and takes full responsibility for the integrity of data and the accuracy of data analysis. This study was supported by National Institutes of Health grants UL1 RR024992 (Clinical Translational Science Award), DK 56341 (Nutrition and Obesity Research Center), DK 20579 (Diabetes Research Center), DK 37948, a grant from the Longer Life Foundation, and support from the Kilo Foundation. Publisher Copyright: © 2016 AGA Institute.

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Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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