Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Elisa Fabbrini; Courtney Tiemann Luecking; Latisha Love-Gregory; Adewole L. Okunade; Mihoko Yoshino; Gemma Fraterrigo; Bruce W. Patterson; Samuel Klein

doi:10.1053/j.gastro.2015.09.003

Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Elisa Fabbrini, Courtney Tiemann Luecking, Latisha Love-Gregory, Adewole L. Okunade, Mihoko Yoshino, Gemma Fraterrigo, Bruce W. Patterson, Samuel Klein

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

Original language	English
Pages (from-to)	79-81.e2
Journal	Gastroenterology
Volume	150
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2015.09.003
State	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© 2016 AGA Institute.

Keywords

Fatty Acid Oxidation
Overweight
VLDL
apoB100

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1053/j.gastro.2015.09.003

Cite this

@article{e46dc442b1954a0794424b6f9d02b955,

title = "Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity",

abstract = "Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.",

keywords = "Fatty Acid Oxidation, Overweight, VLDL, apoB100",

author = "Elisa Fabbrini and {Tiemann Luecking}, Courtney and Latisha Love-Gregory and Okunade, {Adewole L.} and Mihoko Yoshino and Gemma Fraterrigo and Patterson, {Bruce W.} and Samuel Klein",

note = "Publisher Copyright: {\textcopyright} 2016 AGA Institute.",

year = "2016",

month = jan,

day = "1",

doi = "10.1053/j.gastro.2015.09.003",

language = "English",

volume = "150",

pages = "79--81.e2",

number = "1",

}

TY - JOUR

T1 - Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

AU - Fabbrini, Elisa

AU - Tiemann Luecking, Courtney

AU - Love-Gregory, Latisha

AU - Okunade, Adewole L.

AU - Yoshino, Mihoko

AU - Fraterrigo, Gemma

AU - Patterson, Bruce W.

AU - Klein, Samuel

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

AB - Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.

KW - Fatty Acid Oxidation

KW - Overweight

KW - VLDL

KW - apoB100

UR - http://www.scopus.com/inward/record.url?scp=84952714964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952714964&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2015.09.003

DO - 10.1053/j.gastro.2015.09.003

M3 - Article

C2 - 26376348

AN - SCOPUS:84952714964

SN - 0016-5085

VL - 150

SP - 79-81.e2

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Physiological Mechanisms of Weight Gain-Induced Steatosis in People with Obesity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this