Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.
|State||Published - Jan 1 2016|
Bibliographical noteFunding Information:
The authors thank Emily Lake for assistance in recruiting the study subjects, Freida Custodio, and Jennifer Shew for technical assistance, Melisa Moore, Kathryn Gratza and the staff of the Clinical Research Unit for help in performing the studies, and the study subjects for their participation. Dr. Samuel Klein is the guarantor of this work, had full access to all the data, and takes full responsibility for the integrity of data and the accuracy of data analysis. This study was supported by National Institutes of Health grants UL1 RR024992 (Clinical Translational Science Award), DK 56341 (Nutrition and Obesity Research Center), DK 20579 (Diabetes Research Center), DK 37948, a grant from the Longer Life Foundation, and support from the Kilo Foundation.
© 2016 AGA Institute.
- Fatty Acid Oxidation
ASJC Scopus subject areas