Physiopathologie et modalités thérapeutiques des dyskinésies induites à la L-Dopa

Translated title of the contribution: Pathophysiology and therapy of L-Dopa-induced dyskinesia

A. Hadj Tahar, E. Bézard, R. Grondin, C. E. Gross, P. J. Bédard

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Involuntary movements, or dyskinesias, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically evolved in the last few years. The present review presents: 1) the current understanding of dyskinesia pathophysiology and 2) the therapeutic modalities, mainly non-dopaminergic, available or in development. We here show that the questions raised by the dyskinesia may have a clinically-driven pharmacological answer: the symptomatic treatment of dyskinesia, the prevention of the priming and the de-priming of the neural networks.

Translated title of the contributionPathophysiology and therapy of L-Dopa-induced dyskinesia
Original languageFrench
Pages (from-to)1125-1142
Number of pages18
JournalRevue Neurologique
Volume159
Issue number12
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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