Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in Vertebrates

E. O. Anderson, E. R. Schneider, S. N. Bagriantsev

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Mechanosensitivity is a fundamental physiological capacity, which pertains to all life forms. Progress has been made with regard to understanding mechanosensitivity in bacteria, flies, and worms. In vertebrates, however, the molecular identity of mechanotransducers in somatic and neuronal cells has only started to appear. The Piezo family of mechanogated ion channels marks a pivotal milestone in understanding mechanosensitivity. Piezo1 and Piezo2 have now been shown to participate in a number of processes, ranging from arterial modeling to sensing muscle stretch. In this review, we focus on Piezo2 and its role in mediating mechanosensation and proprioception in vertebrates.

Original languageEnglish
Pages (from-to)197-217
Number of pages21
JournalCurrent Topics in Membranes
Volume79
DOIs
StatePublished - 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

  • Dorsal root ganglia
  • Mechanoreception
  • Mechanosensitivity
  • Mechanotransduction
  • Piezo2
  • Proprioception
  • Somatosensitivity
  • Trigeminal ganglia

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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