TY - JOUR
T1 - Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
AU - Yu, Jieshi
AU - Sreenivasan, Chithra
AU - Uprety, Tirth
AU - Gao, Rongyuan
AU - Huang, Chen
AU - Lee, Ella J.
AU - Lawson, Steven
AU - Nelson, Julie
AU - Christopher-Hennings, Jane
AU - Kaushik, Radhey S.
AU - Nelson, Eric
AU - Diel, Diego G.
AU - Hause, Ben M.
AU - Li, Feng
AU - Wang, Dan
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.
AB - Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.
UR - http://www.scopus.com/inward/record.url?scp=85100110640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100110640&partnerID=8YFLogxK
U2 - 10.1038/s41541-021-00283-x
DO - 10.1038/s41541-021-00283-x
M3 - Article
AN - SCOPUS:85100110640
VL - 6
JO - npj Vaccines
JF - npj Vaccines
IS - 1
M1 - 22
ER -
