Pilot study of nicardipine for acute ischemic stroke

D. M. Rosenbaum, J. C. Grotta, F. M. Yatsu, C. M. Picone, L. C. Pettigrew, P. Bratina, J. Zabramski, R. Spetzler, L. Lopez, J. Marler, D. Ellis

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The author performed a pilot study of nicardipine (NC), a Ca + + channel blocker, to study its dosing, toxicity, and possible efficacy for hemispheric cerebral infarction within 12 hours (mean 6.9 hr) of onset to determine the advisability of proceeding with a multi-centered controlled trial. NC was administered IV (3 to 7 mg/hr) X 72 hours by titrating dose to mean arterial blood pressure (MABP not <10% of baseline), then orally X 30 days. Forty-three patients have been entered; mean age 63 (range 34-89), 25 male and 18 female. Only 3 had CT evidence of infarct on entry. Results have shown improvement in a 100-point (pt) graded exam (40 pts at entry, 68 pts at 3 months). Of 20 patients completing 3 months' evaluation, 17 improved and none worsened. Sixteen out of 20 were at home and 8 had minimal or no impairment. Mean Barthel's index was 72. Mean maximal serum NC level was 75 ng/mL. MABP decreased from 103 (entry) to 83 (72 hours). A larger controlled study is warranted to determine the efficacy of NC for acute cerebral infarct.

Original languageEnglish
Pages (from-to)1017-1022
Number of pages6
JournalAngiology
Volume41
Issue number11 SUPPL.
StatePublished - 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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