Placental pathologic aberrations in cases of familial idiopathic spontaneous preterm birth

E. A. Defranco; T. S. Jacobs; J. Plunkett; B. P. Chaudhari; P. C. Huettner; L. J. Muglia

doi:10.1016/j.placenta.2011.02.010

Placental pathologic aberrations in cases of familial idiopathic spontaneous preterm birth

E. A. Defranco, T. S. Jacobs, J. Plunkett, B. P. Chaudhari, P. C. Huettner, L. J. Muglia

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: To test the hypothesis that placental histologic characteristics in familial spontaneous preterm birth (sPTB) differ by gestational age (GA) and reflect possible mechanisms of pathogenesis. Study design: Secondary analysis from prospective cohort study in women with sPTB <35 weeks and a first degree family member with PTB. Placental specimens (n = 79) were categorized by maternal and/or fetal inflammatory response (MIR, FIR) and compared among three preterm GA categories. Results: Inflammatory changes were common. MIR was most frequent at the earliest GAs, 85% with PTB <28 weeks [_adjOR 77.5 (95% CI 5, 1213.1)], and 57% at 28-32 weeks [_adjOR 6.1 (0.8, 48.5)] compared to later PTBs occurring at 32-35 weeks (22%). FIR also occurred most frequently in the earliest cases of PTB <28 weeks. Conclusions: Placental inflammatory responses are common in women with familial sPTB. This data suggests that inflammation plays an important role in the onset of parturition in cases otherwise classified as idiopathic or spontaneous in nature, especially at the earliest GAs when neonatal outcomes are the poorest.

Original language	English
Pages (from-to)	386-390
Number of pages	5
Journal	Placenta
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.placenta.2011.02.010
State	Published - May 2011

Funding

The authors would like to thank D. Michael Nelson, M.D., PhD for his assistance with study design and interpretation of results, and Adrienne Stormo, Kristin Lee, M.D., Michael Wangler, M.D., Zachary A.-F. Kistka, M.D., Lisanne Palomar, M.D., and Stephanie Purisch for subject recruitment. This work was supported by a grant from the March of Dimes .

Funders	Funder number
March of Dimes Research Foundation

Keywords

Inflammation
Placental inflammation
Prematurity
Preterm birth
Spontaneous labor

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1016/j.placenta.2011.02.010

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title = "Placental pathologic aberrations in cases of familial idiopathic spontaneous preterm birth",

abstract = "Objective: To test the hypothesis that placental histologic characteristics in familial spontaneous preterm birth (sPTB) differ by gestational age (GA) and reflect possible mechanisms of pathogenesis. Study design: Secondary analysis from prospective cohort study in women with sPTB <35 weeks and a first degree family member with PTB. Placental specimens (n = 79) were categorized by maternal and/or fetal inflammatory response (MIR, FIR) and compared among three preterm GA categories. Results: Inflammatory changes were common. MIR was most frequent at the earliest GAs, 85% with PTB <28 weeks [adjOR 77.5 (95% CI 5, 1213.1)], and 57% at 28-32 weeks [adjOR 6.1 (0.8, 48.5)] compared to later PTBs occurring at 32-35 weeks (22%). FIR also occurred most frequently in the earliest cases of PTB <28 weeks. Conclusions: Placental inflammatory responses are common in women with familial sPTB. This data suggests that inflammation plays an important role in the onset of parturition in cases otherwise classified as idiopathic or spontaneous in nature, especially at the earliest GAs when neonatal outcomes are the poorest.",

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author = "Defranco, {E. A.} and Jacobs, {T. S.} and J. Plunkett and Chaudhari, {B. P.} and Huettner, {P. C.} and Muglia, {L. J.}",

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AU - Defranco, E. A.

AU - Jacobs, T. S.

AU - Plunkett, J.

AU - Chaudhari, B. P.

AU - Huettner, P. C.

AU - Muglia, L. J.

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N2 - Objective: To test the hypothesis that placental histologic characteristics in familial spontaneous preterm birth (sPTB) differ by gestational age (GA) and reflect possible mechanisms of pathogenesis. Study design: Secondary analysis from prospective cohort study in women with sPTB <35 weeks and a first degree family member with PTB. Placental specimens (n = 79) were categorized by maternal and/or fetal inflammatory response (MIR, FIR) and compared among three preterm GA categories. Results: Inflammatory changes were common. MIR was most frequent at the earliest GAs, 85% with PTB <28 weeks [adjOR 77.5 (95% CI 5, 1213.1)], and 57% at 28-32 weeks [adjOR 6.1 (0.8, 48.5)] compared to later PTBs occurring at 32-35 weeks (22%). FIR also occurred most frequently in the earliest cases of PTB <28 weeks. Conclusions: Placental inflammatory responses are common in women with familial sPTB. This data suggests that inflammation plays an important role in the onset of parturition in cases otherwise classified as idiopathic or spontaneous in nature, especially at the earliest GAs when neonatal outcomes are the poorest.

AB - Objective: To test the hypothesis that placental histologic characteristics in familial spontaneous preterm birth (sPTB) differ by gestational age (GA) and reflect possible mechanisms of pathogenesis. Study design: Secondary analysis from prospective cohort study in women with sPTB <35 weeks and a first degree family member with PTB. Placental specimens (n = 79) were categorized by maternal and/or fetal inflammatory response (MIR, FIR) and compared among three preterm GA categories. Results: Inflammatory changes were common. MIR was most frequent at the earliest GAs, 85% with PTB <28 weeks [adjOR 77.5 (95% CI 5, 1213.1)], and 57% at 28-32 weeks [adjOR 6.1 (0.8, 48.5)] compared to later PTBs occurring at 32-35 weeks (22%). FIR also occurred most frequently in the earliest cases of PTB <28 weeks. Conclusions: Placental inflammatory responses are common in women with familial sPTB. This data suggests that inflammation plays an important role in the onset of parturition in cases otherwise classified as idiopathic or spontaneous in nature, especially at the earliest GAs when neonatal outcomes are the poorest.

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KW - Preterm birth

KW - Spontaneous labor

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Placental pathologic aberrations in cases of familial idiopathic spontaneous preterm birth

Abstract

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Keywords

ASJC Scopus subject areas

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