TY - JOUR
T1 - Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects
AU - Fonseca, Vivian A.
AU - Mudaliar, Sunder
AU - Schmidt, B.
AU - Fink, Louis M.
AU - Kern, Philip A.
AU - Henry, Robert R.
PY - 1998
Y1 - 1998
N2 - An association between hyperhomocysteinemia and premature atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM) has recently been described. Little is known about the role of insulin in homocysteine H(e)] metabolism. We measured plasma H(e) concentrations in the fasting state and during a hyperinsulinemic-euglycemic clamp in normal subjects and patients with NIDDM. Plasma H(e) decreased significantly from 7.2 ± 2.6 to 6.0 ± 2.7 mmol/L (P < .01) in normal subjects, but did not change in patients with NIDDM (6.0 ± 2.7 to 5.9 ± 2.5 mmol/L, respectively). These data suggest that plasma H(e) concentrations are regulated by acute hyperinsulinemia in normal subjects, but not in insulin- resistant NIDDM subjects. These abnormalities may have implications for the pathogenesis of premature vascular disease associated with NIDDM.
AB - An association between hyperhomocysteinemia and premature atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM) has recently been described. Little is known about the role of insulin in homocysteine H(e)] metabolism. We measured plasma H(e) concentrations in the fasting state and during a hyperinsulinemic-euglycemic clamp in normal subjects and patients with NIDDM. Plasma H(e) decreased significantly from 7.2 ± 2.6 to 6.0 ± 2.7 mmol/L (P < .01) in normal subjects, but did not change in patients with NIDDM (6.0 ± 2.7 to 5.9 ± 2.5 mmol/L, respectively). These data suggest that plasma H(e) concentrations are regulated by acute hyperinsulinemia in normal subjects, but not in insulin- resistant NIDDM subjects. These abnormalities may have implications for the pathogenesis of premature vascular disease associated with NIDDM.
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U2 - 10.1016/S0026-0495(98)90031-2
DO - 10.1016/S0026-0495(98)90031-2
M3 - Article
C2 - 9627367
AN - SCOPUS:0031781803
SN - 0026-0495
VL - 47
SP - 686
EP - 689
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 6
ER -