Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects

Vivian A. Fonseca, Sunder Mudaliar, B. Schmidt, Louis M. Fink, Philip A. Kern, Robert R. Henry

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

An association between hyperhomocysteinemia and premature atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM) has recently been described. Little is known about the role of insulin in homocysteine H(e)] metabolism. We measured plasma H(e) concentrations in the fasting state and during a hyperinsulinemic-euglycemic clamp in normal subjects and patients with NIDDM. Plasma H(e) decreased significantly from 7.2 ± 2.6 to 6.0 ± 2.7 mmol/L (P < .01) in normal subjects, but did not change in patients with NIDDM (6.0 ± 2.7 to 5.9 ± 2.5 mmol/L, respectively). These data suggest that plasma H(e) concentrations are regulated by acute hyperinsulinemia in normal subjects, but not in insulin- resistant NIDDM subjects. These abnormalities may have implications for the pathogenesis of premature vascular disease associated with NIDDM.

Original languageEnglish
Pages (from-to)686-689
Number of pages4
JournalMetabolism: Clinical and Experimental
Volume47
Issue number6
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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