Abstract
An association between hyperhomocysteinemia and premature atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM) has recently been described. Little is known about the role of insulin in homocysteine H(e)] metabolism. We measured plasma H(e) concentrations in the fasting state and during a hyperinsulinemic-euglycemic clamp in normal subjects and patients with NIDDM. Plasma H(e) decreased significantly from 7.2 ± 2.6 to 6.0 ± 2.7 mmol/L (P < .01) in normal subjects, but did not change in patients with NIDDM (6.0 ± 2.7 to 5.9 ± 2.5 mmol/L, respectively). These data suggest that plasma H(e) concentrations are regulated by acute hyperinsulinemia in normal subjects, but not in insulin- resistant NIDDM subjects. These abnormalities may have implications for the pathogenesis of premature vascular disease associated with NIDDM.
| Original language | English |
|---|---|
| Pages (from-to) | 686-689 |
| Number of pages | 4 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1998 |
Funding
From the Departments of Medicine and Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock, AR; and the University of California at San Diego and Veterans Administration Hospital, San Diego, CA. Submitted July 10, 1997; accepted December 31, 1997. Supported in part by a grant from the Arkansas Affiliate of the American Heart Association. Address reprint requests to Vivian A. Fonseea, MD, VA Medical Center, 4300 W 7th St, Little Rock, AR 72205. Copyright © 1998 by W.B. Saunders Company 0026-0495/98/4706-0011503.00/0
| Funders | Funder number |
|---|---|
| American Heart Association | |
| University Arkansas |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
