Plasma membrane repair: A central process for maintaining cellular homeostasis

Alisa D. Blazek, Brian J. Paleo, Noah Weisleder

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

Plasma membrane repair is a conserved cellular response mediating active resealing of membrane disruptions to maintain homeostasis and prevent cell death and progression of multiple diseases. Cell membrane repair repurposes mechanisms from various cellular functions, including vesicle trafficking, exocytosis, and endocytosis, to mend the broken membrane. Recent studies increased our understanding of membrane repair by establishing the molecular machinery contributing to membrane resealing.

Original languageEnglish
Pages (from-to)438-448
Number of pages11
JournalPhysiology
Volume30
Issue number6
DOIs
StatePublished - Nov 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Int. Union Physiol. Sci./Am. Physiol. Soc.

Funding

FundersFunder number
National Institutes of Health (NIH)
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke CouncilT32NS077984

    ASJC Scopus subject areas

    • Physiology

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