Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

Erin L. Abner, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Edward J. Goetzl

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume3
Issue number5
DOIs
StatePublished - May 1 2016

Bibliographical note

Publisher Copyright:
© 2016 American Neurological Association.

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology

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