Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.
|Number of pages||5|
|Journal||Annals of Clinical and Translational Neurology|
|State||Published - May 1 2016|
Bibliographical notePublisher Copyright:
© 2016 American Neurological Association.
ASJC Scopus subject areas
- Neuroscience (all)
- Clinical Neurology