Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

Erin L. Abner; Gregory A. Jicha; Leslie M. Shaw; John Q. Trojanowski; Edward J. Goetzl

doi:10.1002/acn3.309

Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

Erin L. Abner, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Edward J. Goetzl

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Abstract

Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ_1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.

Original language	English
Pages (from-to)	399-403
Number of pages	5
Journal	Annals of Clinical and Translational Neurology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1002/acn3.309
State	Published - May 1 2016

Bibliographical note

Publisher Copyright:
© 2016 American Neurological Association.

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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title = "Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging",

abstract = "Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.",

author = "Abner, {Erin L.} and Jicha, {Gregory A.} and Shaw, {Leslie M.} and Trojanowski, {John Q.} and Goetzl, {Edward J.}",

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AU - Jicha, Gregory A.

AU - Shaw, Leslie M.

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AU - Goetzl, Edward J.

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AB - Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.

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Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

Abstract

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