Plasticity, pathology, and Alzheimer's disease

J. W. Geddes, C. W. Cotman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Much basic data support the notion that growth factors are important in the maintenance and repair of the CNS. Although local increases in growth factors might contribute to aberrant growth and senile plaque formation in Alzheimer's disease (AD), the administration of growth factor inhibitors as a therapeutic intervention would be predicted to decrease the vulnerability of remaining healthy neurons. The administration of neurotrophic agents in AD may help to protect and maintain neurons, and thereby minimize neuronal death and the resultant sprouting response.

Original languageEnglish
Pages (from-to)571-573
Number of pages3
JournalNeurobiology of Aging
Issue number5
StatePublished - 1989

Bibliographical note

Copyright 2014 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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