PLASTICITY | Proteomic Approaches to the Analysis of Protein Alterations at the Synapse in Kindling

T. C. Vanaman, S. W. Whiteheart, E. A. Matveeva, J. T. Slevin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Technological advances over the last decade in gel electrophoresis and in mass spectrometry (MS)-based procedures have revolutionized approaches for analyzing proteins. Application of these new techniques, collectively termed proteomics, has permitted the global analysis of protein levels and modification states at very high sensitivities of detection on multiple samples simultaneously. This technology provides a means to analyze proteins, in parallel with analysis of gene expression, in tissues and cells under differing treatment conditions and in differing settings (e.g., disease vs. normal). This article presents an overview of current technologies used for 2D gel and MS analysis for proteomic studies, and the application of this technology to brain – particularly with emphasis on the kindling model of epilepsy in rat.

Original languageEnglish
Title of host publicationEncyclopedia of Basic Epilepsy Research
Number of pages6
ISBN (Electronic)9780123739612
StatePublished - Jan 1 2009

Bibliographical note

Publisher Copyright:
© 2009 Elsevier Ltd. All rights reserved.


  • 2D gel electrophoresis
  • Epilepsy
  • Kindling
  • Mass spectrometry (MS)
  • Proteomics

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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