Platelet glycoprotein IIb/IIIa inhibition in acute coronary syndromes

Koon Hou Mak, David J. Moliterno

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Acute coronary syndromes are a leading cause of hospitalization in industrialized countries. Current antithrombotic therapy focuses on relatively weak antiplatelet agents and heparin. The advent of inhibitors of the platelet glycoprotein IIb/IIIa receptor, the final common pathway for aggregation, provides a new therapeutic modality. Clinical trials with a total of more than 18,000 patients have clearly shown the benefits of intravenous IIb/IIIa blockade. Overall, at 30 days, 13 fewer deaths or myocardial infarctions occurred for every 1000 patients treated in these trials. This favorable outcome was extended to 6 months, resulting in 16 fewer such events per 1000 patients treated. Importantly, these benefits were not accompanied by an excessive occurrence in bleeding complications or thromb-ocytopenia. To further improve outcomes in this high-risk group of patients, strategies pertaining to prolonged periods of vessel passivation with oral formulations and early or delayed invasive approaches are being studied.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalCurrent Cardiology Reports
Issue number3
StatePublished - 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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