Platelet glycoprotein IIb/IIIa receptor antagonists: Fundamental and pharmacological aspects

Joseph Jozic; David J. Moliterno

doi:10.3109/9780203091494-21

Platelet glycoprotein IIb/IIIa receptor antagonists: Fundamental and pharmacological aspects

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The main adhesion mechanism binding the platelet to the subendothelial matrix is via collagen. There are two main collagen receptors on the platelet membrane, GPIa/IIa and GPVI. GPIa/IIa serves as an anchor for platelets to connect to exposed collagen, 2 while GPVI activates adhesive receptors, including GPIa/IIa, which strengthen collagenplatelet adherence. 3 Collagen, while serving as the scaffolding for platelet adherence, also activates platelets by intracellular second messengers. 4 Other molecules that activate platelets include epinephrine (adrenaline), serotonin, and adenosine diphosphate (ADP), as well as vWF. 5 One of the most potent activators of the platelet is thrombin. The primary thrombin receptor on the platelet is protease-activated receptor 1 (PAR-1). Thrombin, thromboxane A 2 (TXA 2), and ADP directly activate the platelet through G-protein-coupled receptors, leading to platelet aggregation and granule release. 6 The ADP receptors on the platelet are P2Y 1 and P2Y 12.

Original language	English
Title of host publication	Clinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease
Pages	101-105
Number of pages	5
ISBN (Electronic)	9780203091494
DOIs	https://doi.org/10.3109/9780203091494-21
State	Published - Jan 1 2008

Bibliographical note

Publisher Copyright:
© 2008 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business.

ASJC Scopus subject areas

General Medicine
General Pharmacology, Toxicology and Pharmaceutics

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10.3109/9780203091494-21

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title = "Platelet glycoprotein IIb/IIIa receptor antagonists: Fundamental and pharmacological aspects",

abstract = "The main adhesion mechanism binding the platelet to the subendothelial matrix is via collagen. There are two main collagen receptors on the platelet membrane, GPIa/IIa and GPVI. GPIa/IIa serves as an anchor for platelets to connect to exposed collagen, 2 while GPVI activates adhesive receptors, including GPIa/IIa, which strengthen collagenplatelet adherence. 3 Collagen, while serving as the scaffolding for platelet adherence, also activates platelets by intracellular second messengers. 4 Other molecules that activate platelets include epinephrine (adrenaline), serotonin, and adenosine diphosphate (ADP), as well as vWF. 5 One of the most potent activators of the platelet is thrombin. The primary thrombin receptor on the platelet is protease-activated receptor 1 (PAR-1). Thrombin, thromboxane A 2 (TXA 2), and ADP directly activate the platelet through G-protein-coupled receptors, leading to platelet aggregation and granule release. 6 The ADP receptors on the platelet are P2Y 1 and P2Y 12.",

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N2 - The main adhesion mechanism binding the platelet to the subendothelial matrix is via collagen. There are two main collagen receptors on the platelet membrane, GPIa/IIa and GPVI. GPIa/IIa serves as an anchor for platelets to connect to exposed collagen, 2 while GPVI activates adhesive receptors, including GPIa/IIa, which strengthen collagenplatelet adherence. 3 Collagen, while serving as the scaffolding for platelet adherence, also activates platelets by intracellular second messengers. 4 Other molecules that activate platelets include epinephrine (adrenaline), serotonin, and adenosine diphosphate (ADP), as well as vWF. 5 One of the most potent activators of the platelet is thrombin. The primary thrombin receptor on the platelet is protease-activated receptor 1 (PAR-1). Thrombin, thromboxane A 2 (TXA 2), and ADP directly activate the platelet through G-protein-coupled receptors, leading to platelet aggregation and granule release. 6 The ADP receptors on the platelet are P2Y 1 and P2Y 12.

AB - The main adhesion mechanism binding the platelet to the subendothelial matrix is via collagen. There are two main collagen receptors on the platelet membrane, GPIa/IIa and GPVI. GPIa/IIa serves as an anchor for platelets to connect to exposed collagen, 2 while GPVI activates adhesive receptors, including GPIa/IIa, which strengthen collagenplatelet adherence. 3 Collagen, while serving as the scaffolding for platelet adherence, also activates platelets by intracellular second messengers. 4 Other molecules that activate platelets include epinephrine (adrenaline), serotonin, and adenosine diphosphate (ADP), as well as vWF. 5 One of the most potent activators of the platelet is thrombin. The primary thrombin receptor on the platelet is protease-activated receptor 1 (PAR-1). Thrombin, thromboxane A 2 (TXA 2), and ADP directly activate the platelet through G-protein-coupled receptors, leading to platelet aggregation and granule release. 6 The ADP receptors on the platelet are P2Y 1 and P2Y 12.

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Platelet glycoprotein IIb/IIIa receptor antagonists: Fundamental and pharmacological aspects

Abstract

Bibliographical note

ASJC Scopus subject areas

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