Abstract
While it is clear that platelets interact with viruses, the ramifications and mechanisms of those interactions are still being defined for each type of viral infection. HIV/AIDS+ represents a potentially unique example of how viremia affects platelets since the increasing efficacy of antiretroviral therapeutics (ART) has made it a chronic disease that increases the risk of cardiovascular disease. In this opinion article, we discuss some of the open questions about how platelets interact with HIV. What happens to a virion once it binds a platelet? What is the nature of virus-induced platelet activation? Are platelets a normal part of the immune response to viremia that has been co-opted to increase the spread of HIV? The answers to these and similar questions will help define how platelet-directed therapeutics might be used in treating HIV/AIDS+ patients.
Original language | English |
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Pages (from-to) | 208-211 |
Number of pages | 4 |
Journal | Platelets |
Volume | 33 |
Issue number | 2 |
DOIs | |
State | Published - 2022 |
Bibliographical note
Publisher Copyright:© 2022 Taylor & Francis Group, LLC.
Keywords
- AIDS
- HIV
- endocytosis
- platelets
- viremia
ASJC Scopus subject areas
- Hematology