Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: A study in dogs

Marcelo Diniz Carvalho, Fabrícia Ferreira Suaid, Mauro Pedrine Santamaria, Marcio Zaffalon Casati, Francisco Humberto Nociti, Antonio Wilson Sallum, Enilson Antônio Sallum

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


OBJECTIVE: This study was designed to evaluate, histomorphometrically, the association of platelet-rich plasma (PRP) and bioactive glass (BG) in the treatment of periodontal intrabony defects. MATERIAL AND METHODS: Nine mongrel dogs were included in the study. Three-wall intrabony defects were surgically created at the mesial and distal aspect of first mandibular molar and exposed to plaque accumulation for 1 month. The defects were randomly assigned to the groups: control, BG, PRP, PRP+BG. Dogs were sacrificed 90 days after the surgeries. The histometric parameters evaluated were: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone, defect extension and area of new bone filling the defect. RESULTS: A superior area of new bone was observed in PRP+BG and BG (13.80±2.32 mm2 and 15.63±2.64 mm2, respectively) when compared to the other groups (8.19±1.46 mm2 and 8.81±1.47 mm2 for control and PRP, respectively). No statistically significant differences were observed in the remaining parameters. CONCLUSIONS: Within the limits of this study, it may be concluded that PRP failed to provide statistically significant improvements in the histometric parameters.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalJournal of Applied Oral Science
Issue number1
StatePublished - 2011


  • Dogs
  • Periodontal diseases
  • Platelet-rich plasma (PRP)
  • Regeneration

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects: A study in dogs'. Together they form a unique fingerprint.

Cite this