TY - JOUR
T1 - Platelet-rich plasma plus bioactive glass in the treatment of intra-bony defects
T2 - A study in dogs
AU - Carvalho, Marcelo Diniz
AU - Suaid, Fabrícia Ferreira
AU - Santamaria, Mauro Pedrine
AU - Casati, Marcio Zaffalon
AU - Nociti, Francisco Humberto
AU - Sallum, Antonio Wilson
AU - Sallum, Enilson Antônio
PY - 2011
Y1 - 2011
N2 - OBJECTIVE: This study was designed to evaluate, histomorphometrically, the association of platelet-rich plasma (PRP) and bioactive glass (BG) in the treatment of periodontal intrabony defects. MATERIAL AND METHODS: Nine mongrel dogs were included in the study. Three-wall intrabony defects were surgically created at the mesial and distal aspect of first mandibular molar and exposed to plaque accumulation for 1 month. The defects were randomly assigned to the groups: control, BG, PRP, PRP+BG. Dogs were sacrificed 90 days after the surgeries. The histometric parameters evaluated were: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone, defect extension and area of new bone filling the defect. RESULTS: A superior area of new bone was observed in PRP+BG and BG (13.80±2.32 mm2 and 15.63±2.64 mm2, respectively) when compared to the other groups (8.19±1.46 mm2 and 8.81±1.47 mm2 for control and PRP, respectively). No statistically significant differences were observed in the remaining parameters. CONCLUSIONS: Within the limits of this study, it may be concluded that PRP failed to provide statistically significant improvements in the histometric parameters.
AB - OBJECTIVE: This study was designed to evaluate, histomorphometrically, the association of platelet-rich plasma (PRP) and bioactive glass (BG) in the treatment of periodontal intrabony defects. MATERIAL AND METHODS: Nine mongrel dogs were included in the study. Three-wall intrabony defects were surgically created at the mesial and distal aspect of first mandibular molar and exposed to plaque accumulation for 1 month. The defects were randomly assigned to the groups: control, BG, PRP, PRP+BG. Dogs were sacrificed 90 days after the surgeries. The histometric parameters evaluated were: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone, defect extension and area of new bone filling the defect. RESULTS: A superior area of new bone was observed in PRP+BG and BG (13.80±2.32 mm2 and 15.63±2.64 mm2, respectively) when compared to the other groups (8.19±1.46 mm2 and 8.81±1.47 mm2 for control and PRP, respectively). No statistically significant differences were observed in the remaining parameters. CONCLUSIONS: Within the limits of this study, it may be concluded that PRP failed to provide statistically significant improvements in the histometric parameters.
KW - Dogs
KW - Periodontal diseases
KW - Platelet-rich plasma (PRP)
KW - Regeneration
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U2 - 10.1590/S1678-77572011000100016
DO - 10.1590/S1678-77572011000100016
M3 - Article
AN - SCOPUS:79953016528
SN - 1678-7757
VL - 19
SP - 82
EP - 89
JO - Journal of Applied Oral Science
JF - Journal of Applied Oral Science
IS - 1
ER -