Plk1 inhibitors in cancer therapy: From laboratory to clinics

Rosie Elizabeth Ann Gutteridge, Mary Ann Ndiaye, Xiaoqi Liu, Nihal Ahmad

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

Polo-like kinase 1 (Plk1) overexpression has been shown to occur in a wide range of tumors, prompting research and development of Plk1 inhibitors as a means of cancer treatment. This review discusses recent advances in the development of Plk1 inhibitors for cancer management. Plk1 inhibition has been shown to cause mitotic block and apoptosis of cells with higher mitotic index and therefore higher Plk1 expression. The potential of Plk1 inhibitors as cancer therapeutics has been widely investigated. However, a complete understanding of Plk1 biology/mechanism is yet to be fully achieved. Resistance to certain chemotherapeutic drugs has been linked to Plk1 overexpression, and Plk1-mediated mitotic events such as microtubule rearrangement have been found to reduce the efficacy of chemotherapeutic agents. The Plk1 inhibitor volasertib has shown considerable promise in clinical studies, having reached phase III trials. However, preclinical success with Plk1 inhibitors has not translated well into clinical success. In our view, combined therapies targeting other relevant pathways together with Plk1 may be vital to combat issues observed with monotherapy, especially resistance. In addition, research should also be directed toward understanding the mechanisms of Plk1 and designing additional next generations of specific, potent Plk1 inhibitors to target cancer.

Original languageEnglish
Pages (from-to)1427-1435
Number of pages9
JournalMolecular Cancer Therapeutics
Volume15
Issue number7
DOIs
StatePublished - Jul 2016

Bibliographical note

Funding Information:
This work was partially supported by funding from the NIH (R01AR059130 and R01CA176748; to N. Ahmad) and the Department of Veterans Affairs (VA Merit Review Award 1I01BX001008; to N. Ahmad).

Publisher Copyright:
© 2016 American Association for Cancer Research.

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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