Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

X. Shawn Liu, Hongchang Li, Bing Song, Xiaoqi Liu

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

In response to G2 DNA damage, the p53 pathway is activated to lead to cell-cycle arrest, but how p53 is eliminated during the subsequent recovery process is poorly understood. It has been established that Polo-like kinase 1 (Plk1) controls G2 DNA-damage recovery. However, whether Plk1 activity contributes to p53 inactivation during this process is unknown. In this study, we show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 at Ser 435 promotes its nuclear localization, and thus shuttles p53 out of the nucleus to lead to its degradation during the recovery.

Original languageEnglish
Pages (from-to)626-632
Number of pages7
JournalEMBO Reports
Volume11
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • GTSE1
  • Plk1
  • checkpoint recovery
  • p53
  • phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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