Abstract
Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process. It is well established that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at other stages of the cell cycle. Here we summarize the functions of Plk1 during DNA replication, focusing on the molecular events related to Origin Recognition Complex (ORC), the complex that is essential for the initiation of DNA replication. Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.
| Original language | English |
|---|---|
| Article number | 3 |
| Journal | Cell Division |
| Volume | 7 |
| DOIs | |
| State | Published - Feb 6 2012 |
Bibliographical note
Funding Information:We appreciate Eleanor Erikson for critical reading of the paper. Support from the Purdue University Center for Cancer Research Small Grants Program is gratefully acknowledged. This work is also supported by National Science Foundation (MCB-1049693), Elsa U. Pardee Foundation (204937), and Uniting against Lung Cancer (09107892).
Keywords
- DNA replication
- ORC2
- Phosphorylation
- Plk1
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology