Polo-like kinase 1 (Plk1): An Unexpected Player in DNA Replication

Bing Song; X. Shawn Liu; Xiaoqi Liu

doi:10.1186/1747-1028-7-3

Polo-like kinase 1 (Plk1): An Unexpected Player in DNA Replication

Bing Song
, X. Shawn Liu
, Xiaoqi Liu

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process. It is well established that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at other stages of the cell cycle. Here we summarize the functions of Plk1 during DNA replication, focusing on the molecular events related to Origin Recognition Complex (ORC), the complex that is essential for the initiation of DNA replication. Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.

Original language	English
Article number	3
Journal	Cell Division
Volume	7
DOIs	https://doi.org/10.1186/1747-1028-7-3
State	Published - Feb 6 2012

Bibliographical note

Funding Information:
We appreciate Eleanor Erikson for critical reading of the paper. Support from the Purdue University Center for Cancer Research Small Grants Program is gratefully acknowledged. This work is also supported by National Science Foundation (MCB-1049693), Elsa U. Pardee Foundation (204937), and Uniting against Lung Cancer (09107892).

Funding

We appreciate Eleanor Erikson for critical reading of the paper. Support from the Purdue University Center for Cancer Research Small Grants Program is gratefully acknowledged. This work is also supported by National Science Foundation (MCB-1049693), Elsa U. Pardee Foundation (204937), and Uniting against Lung Cancer (09107892).

Funders	Funder number
Purdue Climate Change Research Center, Purdue University
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China	MCB-1049693
Elsa U Pardee Foundation	09107892, 204937

Keywords

DNA replication
ORC2
Phosphorylation
Plk1

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1186/1747-1028-7-3

Cite this

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title = "Polo-like kinase 1 (Plk1): An Unexpected Player in DNA Replication",

abstract = "Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process. It is well established that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at other stages of the cell cycle. Here we summarize the functions of Plk1 during DNA replication, focusing on the molecular events related to Origin Recognition Complex (ORC), the complex that is essential for the initiation of DNA replication. Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.",

keywords = "DNA replication, ORC2, Phosphorylation, Plk1",

author = "Bing Song and Liu, \{X. Shawn\} and Xiaoqi Liu",

note = "Funding Information: We appreciate Eleanor Erikson for critical reading of the paper. Support from the Purdue University Center for Cancer Research Small Grants Program is gratefully acknowledged. This work is also supported by National Science Foundation (MCB-1049693), Elsa U. Pardee Foundation (204937), and Uniting against Lung Cancer (09107892).",

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doi = "10.1186/1747-1028-7-3",

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T1 - Polo-like kinase 1 (Plk1)

T2 - An Unexpected Player in DNA Replication

AU - Song, Bing

AU - Liu, X. Shawn

AU - Liu, Xiaoqi

N1 - Funding Information: We appreciate Eleanor Erikson for critical reading of the paper. Support from the Purdue University Center for Cancer Research Small Grants Program is gratefully acknowledged. This work is also supported by National Science Foundation (MCB-1049693), Elsa U. Pardee Foundation (204937), and Uniting against Lung Cancer (09107892).

PY - 2012/2/6

Y1 - 2012/2/6

N2 - Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process. It is well established that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at other stages of the cell cycle. Here we summarize the functions of Plk1 during DNA replication, focusing on the molecular events related to Origin Recognition Complex (ORC), the complex that is essential for the initiation of DNA replication. Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.

AB - Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process. It is well established that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at other stages of the cell cycle. Here we summarize the functions of Plk1 during DNA replication, focusing on the molecular events related to Origin Recognition Complex (ORC), the complex that is essential for the initiation of DNA replication. Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.

KW - DNA replication

KW - ORC2

KW - Phosphorylation

KW - Plk1

UR - https://www.scopus.com/pages/publications/84862794545

UR - https://www.scopus.com/pages/publications/84862794545#tab=citedBy

U2 - 10.1186/1747-1028-7-3

DO - 10.1186/1747-1028-7-3

M3 - Review article

C2 - 22309699

AN - SCOPUS:84862794545

SN - 1747-1028

VL - 7

JO - Cell Division

JF - Cell Division

M1 - 3

ER -

Polo-like kinase 1 (Plk1): An Unexpected Player in DNA Replication

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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