Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report

Ben Shen; Yi Qiang Cheng; Steven D. Christenson; Hui Jiang; Jianhua Ju; Hyung Jin Kwon; Si Kyu Lim; Wen Liu; Koichi Nonaka; Jeong Woo Seo; Wyatt C. Smith; Scott Standage; Gong Li Tang; Steven Van Lanen; Jian Zhang

Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report

Ben Shen, Yi Qiang Cheng, Steven D. Christenson, Hui Jiang, Jianhua Ju, Hyung Jin Kwon, Si Kyu Lim, Wen Liu, Koichi Nonaka, Jeong Woo Seo, Wyatt C. Smith, Scott Standage, Gong Li Tang, Steven Van Lanen, Jian Zhang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

10 Scopus citations

Abstract

The archetypical polyketide synthases (PKSs), known as type I, II, and III PKSs, have accounted for the vast structural diversities embodied by polyketide natural products, but recent progress in polyketide biosynthesis clearly suggests much greater diversity for PKS mechanism and structure. We have previously argued the emergence of novel PKSs and cautioned the oversimplification of polyketide biosynthesis according to the type I, II, and III PKS paradigms on the basis of our studies on the biosynthesis of the enediynes, the macrotetrolides, and leinamycin. We present here a brief progress report on our current effort to mechanistically characterize these novel PKSs.

Original language	English
Title of host publication	Polyketides Biosynthesis, Biological Activity, and Genetic Engineering
Editors	Agnes Rimando, Scott Baerson
Pages	154-166
Number of pages	13
State	Published - 2007

Publication series

Name	ACS Symposium Series
Volume	955
ISSN (Print)	0097-6156

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

Cite this

Shen, B., Cheng, Y. Q., Christenson, S. D., Jiang, H., Ju, J., Kwon, H. J., Lim, S. K., Liu, W., Nonaka, K., Seo, J. W., Smith, W. C., Standage, S., Tang, G. L., Van Lanen, S., & Zhang, J. (2007). Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report. In A. Rimando, & S. Baerson (Eds.), Polyketides Biosynthesis, Biological Activity, and Genetic Engineering (pp. 154-166). (ACS Symposium Series; Vol. 955).

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title = "Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report",

abstract = "The archetypical polyketide synthases (PKSs), known as type I, II, and III PKSs, have accounted for the vast structural diversities embodied by polyketide natural products, but recent progress in polyketide biosynthesis clearly suggests much greater diversity for PKS mechanism and structure. We have previously argued the emergence of novel PKSs and cautioned the oversimplification of polyketide biosynthesis according to the type I, II, and III PKS paradigms on the basis of our studies on the biosynthesis of the enediynes, the macrotetrolides, and leinamycin. We present here a brief progress report on our current effort to mechanistically characterize these novel PKSs.",

author = "Ben Shen and Cheng, {Yi Qiang} and Christenson, {Steven D.} and Hui Jiang and Jianhua Ju and Kwon, {Hyung Jin} and Lim, {Si Kyu} and Wen Liu and Koichi Nonaka and Seo, {Jeong Woo} and Smith, {Wyatt C.} and Scott Standage and Tang, {Gong Li} and {Van Lanen}, Steven and Jian Zhang",

year = "2007",

language = "English",

isbn = "0841239789",

series = "ACS Symposium Series",

pages = "154--166",

editor = "Agnes Rimando and Scott Baerson",

booktitle = "Polyketides Biosynthesis, Biological Activity, and Genetic Engineering",

}

Shen, B, Cheng, YQ, Christenson, SD, Jiang, H, Ju, J, Kwon, HJ, Lim, SK, Liu, W, Nonaka, K, Seo, JW, Smith, WC, Standage, S, Tang, GL, Van Lanen, S & Zhang, J 2007, Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report. in A Rimando & S Baerson (eds), Polyketides Biosynthesis, Biological Activity, and Genetic Engineering. ACS Symposium Series, vol. 955, pp. 154-166.

Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report. / Shen, Ben; Cheng, Yi Qiang; Christenson, Steven D. et al.
Polyketides Biosynthesis, Biological Activity, and Genetic Engineering. ed. / Agnes Rimando; Scott Baerson. 2007. p. 154-166 (ACS Symposium Series; Vol. 955).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Christenson, Steven D.

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AU - Ju, Jianhua

AU - Kwon, Hyung Jin

AU - Lim, Si Kyu

AU - Liu, Wen

AU - Nonaka, Koichi

AU - Seo, Jeong Woo

AU - Smith, Wyatt C.

AU - Standage, Scott

AU - Tang, Gong Li

AU - Van Lanen, Steven

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Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report

Abstract

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ASJC Scopus subject areas

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