TY - JOUR
T1 - Polymer nanoassemblies with solvato- and halo-fluorochromism for drug release monitoring and metastasis imaging
AU - Reichel, Derek
AU - Rychahou, Piotr
AU - Bae, Younsoo
N1 - Publisher Copyright:
© 2015 Future Science Ltd.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/10
Y1 - 2015/10
N2 - Background: Theranostics, an emerging technique that combines therapeutic and diagnostic modalities for various diseases, holds promise to detect cancer in early stages, eradicate metastatic tumors and ultimately reduce cancer mortality. Methods & results: This study reports unique polymer nanoassemblies that increase fluorescence intensity upon addition of hydrophobic drugs and either increase or decrease fluorescence intensity in acidic environments, depending on nanoparticle core environment properties. Extensive spectroscopic analyses were performed to determine optimal excitation and emission wavelengths, which enabled real time measurement of drugs releasing from the nanoassemblies and ex vivo imaging of acidic liver metastatic tumors from mice. Conclusion: Polymer nanoassemblies with solvato- and halo-fluorochromic properties are promising platforms to develop novel theranostic tools for the detection and treatment of metastatic tumors.
AB - Background: Theranostics, an emerging technique that combines therapeutic and diagnostic modalities for various diseases, holds promise to detect cancer in early stages, eradicate metastatic tumors and ultimately reduce cancer mortality. Methods & results: This study reports unique polymer nanoassemblies that increase fluorescence intensity upon addition of hydrophobic drugs and either increase or decrease fluorescence intensity in acidic environments, depending on nanoparticle core environment properties. Extensive spectroscopic analyses were performed to determine optimal excitation and emission wavelengths, which enabled real time measurement of drugs releasing from the nanoassemblies and ex vivo imaging of acidic liver metastatic tumors from mice. Conclusion: Polymer nanoassemblies with solvato- and halo-fluorochromic properties are promising platforms to develop novel theranostic tools for the detection and treatment of metastatic tumors.
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U2 - 10.4155/tde.15.59
DO - 10.4155/tde.15.59
M3 - Article
C2 - 26446432
AN - SCOPUS:84948683466
SN - 2041-5990
VL - 6
SP - 1221
EP - 1237
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 10
ER -