Polymer nanoassemblies with solvato- and halo-fluorochromism for drug release monitoring and metastasis imaging

Derek Reichel, Piotr Rychahou, Younsoo Bae

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Theranostics, an emerging technique that combines therapeutic and diagnostic modalities for various diseases, holds promise to detect cancer in early stages, eradicate metastatic tumors and ultimately reduce cancer mortality. Methods & results: This study reports unique polymer nanoassemblies that increase fluorescence intensity upon addition of hydrophobic drugs and either increase or decrease fluorescence intensity in acidic environments, depending on nanoparticle core environment properties. Extensive spectroscopic analyses were performed to determine optimal excitation and emission wavelengths, which enabled real time measurement of drugs releasing from the nanoassemblies and ex vivo imaging of acidic liver metastatic tumors from mice. Conclusion: Polymer nanoassemblies with solvato- and halo-fluorochromic properties are promising platforms to develop novel theranostic tools for the detection and treatment of metastatic tumors.

Original languageEnglish
Pages (from-to)1221-1237
Number of pages17
JournalTherapeutic Delivery
Volume6
Issue number10
DOIs
StatePublished - Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 Future Science Ltd.

ASJC Scopus subject areas

  • Pharmaceutical Science

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