Polymer nanoparticulate drug delivery and combination cancer therapy

Pengxiao Cao, Younsoo Bae

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

This review describes the scientific background, current achievement and future perspective of combination therapy using polymer nanoparticle drug carriers in cancer treatment. Nanotechnology-based drug delivery is expected to dramatically change combination cancer therapy by controlling accumulation and distribution patterns of multiple drugs selectively in disease sites. Rationally designed polymer materials can produce functional nanoparticulate drug carriers that can be used in various biomedical applications. In comparison with conventional drug combination approaches, using polymer nanoparticle drug carriers appears to suppress tumor growth more efficiently, potentially overcoming multidrug resistance in many cancers. It also provides versatile combination options for a variety of therapeutic agents, molecular targeting agents and nucleotide drugs.

Original languageEnglish
Pages (from-to)1471-1480
Number of pages10
JournalFuture Oncology
Volume8
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • biomaterials
  • cancer
  • chemotherapy
  • combination therapy
  • drug delivery
  • drug formulation
  • gene therapy
  • nanotechnology
  • pharmaceutical science
  • polymer nanoparticles

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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